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Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (AA 473-486) antibody

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Antigen
Synonyms RIPK3, RIP3, 2610528K09Rik, AW107945, Rip3, Hcyp2
Epitope
AA 473-486
(32), (20), (16), (15), (10), (6), (5), (5), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus)
(118), (39), (15), (7), (6), (4), (2), (1)
Host
Rabbit
(123), (24)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (7), (5), (5), (5), (5), (1)
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(130), (61), (61), (23), (7), (3), (3), (2), (2), (1), (1), (1)
Pubmed 3 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen RIP3 antibody was raised against a peptide corresponding to amino acids 473 to 486 of Murine RIP3.
Isotype IgG
Specificity This antibody detects RIP3.
Cross-Reactivity (Details) Species reactivity (tested):Mouse, Rat.
Purification Peptide Affinity Chromatography
Alternative Name RIPK3 / RIP3 (RIPK3 Antibody Abstract)
Background Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3 (1-3). RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF-kB activation. Overexpression of RIP3 induces apoptosis and NF-kappaB activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues (2,3).Synonyms: RIP-3, RIP-like protein kinase 3, Receptor-interacting protein 3, Receptor-interacting serine/threonine-protein kinase 3
Molecular Weight 57 kDa
Gene ID 56532
UniProt Q9QZL0
Pathways
Application Notes ELISA. Western blot: 0.5 to 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS, 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunofluorescence (IF) image for anti-Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (AA 473-486) antibody (ABIN500612) Immunofluorescence of RIP3 in Rat Kidney cells with RIP3 antibody at 20 µg/ml.
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (AA 473-486) antibody (ABIN500612) Immunohistochemistry of RIP3 in rat kidney tissue with RIP3 antibody at 5 μg/ml.
Western Blotting (WB) image for anti-Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (AA 473-486) antibody (ABIN500612) Western blot analysis of RIP3 in mouse 3T3 whole cell lysate in the absence (A) or pr...
Background publications Pazdernik, Donner, Goebl et al.: "Mouse receptor interacting protein 3 does not contain a caspase-recruiting or a death domain but induces apoptosis and activates NF-kappaB." in: Molecular and cellular biology, Vol. 19, Issue 10, pp. 6500-8, 2000 (PubMed).

Sun, Lee, Navas et al.: "RIP3, a novel apoptosis-inducing kinase." in: The Journal of biological chemistry, Vol. 274, Issue 24, pp. 16871-5, 1999 (PubMed).

Yu, Huang, Shen et al.: "Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB." in: Current biology : CB, Vol. 9, Issue 10, pp. 539-42, 1999 (PubMed).

Catalog No. ABIN500612
$467.50
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