anti-NFAT5 antibody (Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive) (Middle Region)

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Antigen
Synonyms zgc:63502, wu:fi46f11, TonEBP, NFAT5, nfatz, orebp, nf-at5, nfatl1, tonebp, DKFZp469P1514, AI225870, B130038B15Rik, CAG-8, CAG80, NFATL1, OREBP, mKIAA0827, NF-AT5, NFATZ, TONEBP, Nfat
Alternatives
Epitope
Middle Region
(18), (9), (6), (3), (2), (2), (2), (2), (2), (1), (1), (1)
Reactivity
Human
(64), (49), (29)
Host
Rabbit
(61), (5)
Clonality
Polyclonal
Conjugate
This NFAT5 antibody is un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(29), (28), (22), (12), (10), (6), (2)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the middle region of human NFAT5
Blocking Peptide Blocking peptide for this product available: Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive (NFAT5) (Middle Region) peptide (ABIN980637)
Sequence PGQPQNEGQP PVTTLLSQQM PENSPLASSI NTNQNIEKID LLVSLQNQGN
Predicted Reactivity Guinea pig : 100 %, Human : 100 %, Bovine : 90 %, Rabbit : 90 %, Dog : 80 %, Horse : 80 %, Pig : 80 %
Characteristics This is a rabbit polyclonal antibody against NFAT5. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name NFAT5 (NFAT5 Antibody Abstract)
Background NFAT5 is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements.The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene.
Molecular Weight 166 kDa
Gene ID 10725
NCBI Accession NP_006590, NM_006599
UniProt O94916
Research Area Chromatin and Nuclear Signaling, Transcription Factors, Adaptive Immunity
Pathways RTK Signaling, WNT Signaling
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 1531 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-NFAT5 antibody (Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive) (Middle Region) (ABIN501747) WB Suggested Anti-NFAT5 Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
Background publications Zhou, Ferraris, Dmitrieva et al.: "MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38delta." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 14, pp. 5620-5, 2008 (PubMed).

Catalog No. ABIN501747
$289.00
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