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Details for Product No. ABIN502211

Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3) (N-Term) antibody

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Antigen
Synonyms MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2, Prkmk3, mMKK3b, AW212142, Mkk3, map2k3, zMKK3
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Dog (Canine), Cow (Bovine), Zebrafish (Danio rerio), Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN502211
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-MAP2K3 antibody: synthetic peptide directed towards the N terminal of human MAP2K3
Sequence SKPPAPNPTPPRNLDSRTFITIGDRNFEVEADDLVTISEL GRGAYGVVEK
Predicted Reactivity Human : 100%, Rabbit : 100%, Dog : 92%, Guinea pig : 92%, Horse : 92%, Chicken : 90%, Bovine : 85%, Mouse : 85%, Rat : 85%
Characteristics This is a rabbit polyclonal antibody against MAP2K3. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name MAP2K3
Background MAP2K3 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.
Molecular Weight 36kDa
Gene ID 5606
NCBI Accession NP_002747, NM_002756
UniProt P46734-2
Research Area Kinases/Phosphatases
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-MAP2K3 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Prickett, Brautigan: "Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3." in: Molecular and cellular biology, Vol. 27, Issue 12, pp. 4217-27, 2007 (PubMed).

Alternatives for antigen "Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3)", type "Antibodies"
Hosts (131), (39)
Reactivities (168), (89), (76), (22), (22), (11), (9), (8), (2), (2), (1), (1), (1), (1)
Applications (140), (57), (48), (39), (35), (26), (15), (7), (3), (3), (2), (2), (1), (1)
Conjugates (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1)
Epitopes (34), (17), (8), (7), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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