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MITF antibody (AA 150-427)
MITF
Reactivity: Human
WB, IHC
Host: Mouse
Monoclonal
ABM1H91
unconjugated
Product Details anti-MITF Antibody
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Target
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MITF
(Microphthalmia-Associated Transcription Factor (MITF))
Binding Specificity
All epitopes for MITF antibodies
AA 150-427
Reactivity
All reactivities for MITF antibodies
Human
Host
All hosts for MITF antibodies
Mouse
Clonality
All clonalities for MITF antibodies
Monoclonal
Conjugate
All conjugates for MITF antibodies
This MITF antibody is un-conjugated
Application
All applications for MITF antibodies
Western Blotting (WB), Immunohistochemistry (IHC)
Cross-Reactivity
Mouse (Murine)
Purification
Protein G Chromatography
Immunogen
A partial length recombinant MITF protein (amino acids 150-427) was used as the immunogen for this antibody.
Clone
ABM1H91
Isotype
IgG1 kappa
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Alternatives
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Application Details
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Application Notes
WB: 2-4 μg/mL, IHC: 10 μg/mL
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
PBS containing 0.05 % BSA, PH 7.4
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Target Details for MITF
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Target
MITF
(Microphthalmia-Associated Transcription Factor (MITF))
Alternative Name
MITF (MITF Products )
Synonyms
MITF antibody, ws2a antibody, mitfa antibody, MITF-A antibody, LOC100313655 antibody, mitfb antibody, CMM8 antibody, MI antibody, WS2 antibody, WS2A antibody, bHLHe32 antibody, BCC2 antibody, Bhlhe32 antibody, Gsfbcc2 antibody, Vitiligo antibody, Wh antibody, bw antibody, mi antibody, vit antibody, MITF-H antibody, MITF-M antibody, CMI9 antibody, melanogenesis associated transcription factor antibody, microphthalmia-associated transcription factor antibody, microphthalmia-associated transcription factor S homeolog antibody, Microphthalmia antibody, MITF antibody, mitf antibody, LOC100313655 antibody, mitf.S antibody, LOC100534525 antibody, MICROP antibody, Mitf antibody
Background
MITF (Microphthalmia-associated transcription factor) is a basic helix-loop-helix leucine zipper (bHLH-Zip) family factor, involved in lineage-specific pathway regulation of many types of cells including osteoclasts, melanocytes, retinal pigment epithelial cells, mast cells and natural killer cells. It plays a critical role in melanogenesis as a transcriptional activator of tyrosinase, TRP-1, and TRP-2. Moreover, it regulates specification, survival, and proliferation of normal melanocytes, and controls proliferation, migration and invasion of melanoma cells. MITF is the most characterized member of the MIT family, mutations of which can lead to diseases such as Melanoma, Waardenburg syndrome, and Tietz syndrome.
Molecular Weight
30 kDa
Gene ID
4286
UniProt
O75030
Pathways
Chromatin Binding
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