anti-Retinoblastoma Binding Protein 8 antibody (RBBP8) (C-Term)

Details for Product anti-RBBP8 Antibody No. ABIN503204, Supplier: Login to see New
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Antigen
Synonyms CtIP, RBBP8, RBBP-8, RIM, SAE2, DKFZp469K0714, COM1, CTIP, JWDS, SCKL2, 9930104E21Rik, RGD1308872
Alternatives
Epitope
C-Term
(27), (15), (10), (6), (4), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Dog (Canine), Human
(99), (31), (15), (3)
Host
Rabbit
(86), (9), (4)
Clonality
Polyclonal
Conjugate
This Retinoblastoma Binding Protein 8 antibody is un-conjugated
(3), (3), (3), (3), (3), (3), (1)
Application
Western Blotting (WB)
(68), (58), (30), (10), (7), (7), (5), (2), (2), (1), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the C terminal of human RBBP8
Blocking Peptide Blocking peptide for this product available: Retinoblastoma Binding Protein 8 (RBBP8) peptide (ABIN982713)
Sequence ETVDMDCTLV SETVLLKMKK QEQKGEKSSN EERKMNDSLE DMFDRTTHEE
Predicted Reactivity Dog : 100 %, Human : 100 %, Rabbit : 100 %, Bovine : 70 %
Characteristics This is a rabbit polyclonal antibody against RBBP8. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name RBBP8 (RBBP8 Antibody Abstract)
Background RBBP8 is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.
Molecular Weight 98 kDa
Gene ID 5932
NCBI Accession NP_976037, NM_203292
UniProt A6NKN2
Pathways Cell Division Cycle, DNA Damage Repair
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 867 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Retinoblastoma Binding Protein 8 antibody (RBBP8) (C-Term) (ABIN503204) WB Suggested Anti-RBBP8 Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
Western Blotting (WB) image for anti-Retinoblastoma Binding Protein 8 antibody (RBBP8) (C-Term) (ABIN503204) Sample type: 1. HCT116 lysate (50ug)
2. MCF7 lysate (50ug)
3. rCtIP (30n...
Western Blotting (WB) image for anti-Retinoblastoma Binding Protein 8 antibody (RBBP8) (C-Term) (ABIN503204) Host: Rabbit
Target Name: RBBP8
Sample Tissue: Human Fetal Heart
...
Background publications Chen, Nievera, Lee et al.: "Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair." in: The Journal of biological chemistry, Vol. 283, Issue 12, pp. 7713-20, 2008 (PubMed).

Catalog No. ABIN503204
$289.00
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