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Retinoblastoma Binding Protein 8 (RBBP8) (C-Term) antibody

Details for Product No. ABIN503204
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Antigen
Synonyms CtIP, RBBP8, RBBP-8, RIM, SAE2, DKFZp469K0714, COM1, CTIP, JWDS, SCKL2, 9930104E21Rik, RGD1308872
Epitope
C-Term
(16), (7), (5), (3), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Dog (Canine), Human
(62), (30), (23), (12), (12)
Host
Rabbit
(60), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(44), (36), (15), (11), (10), (6), (3), (1), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN503204
289.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic peptide directed towards the C terminal of human RBBP8
Sequence ETVDMDCTLVSETVLLKMKKQEQKGEKSSNEERKMNDSLE DMFDRTTHEE
Predicted Reactivity Dog : 100 %, Human : 100 %, Rabbit : 100 %, Bovine : 70 %
Characteristics This is a rabbit polyclonal antibody against RBBP8. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name RBBP8
Background RBBP8 is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.
Molecular Weight 98 kDa
Gene ID 5932
NCBI Accession NM_203292, NP_976037
UniProt A6NKN2
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 867 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Retinoblastoma Binding Protein 8 (RBBP8) (C-Term) antibody WB Suggested Anti-RBBP8 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Human Placenta
anti-Retinoblastoma Binding Protein 8 (RBBP8) (C-Term) antibody (2) Sample type: 1. HCT116 lysate (50ug)
2. MCF7 lysate (50ug)
3. rCtIP (30ng)
Primary Dilution: 1:1000
Secondary Antibody: anti-Rabbit IR700
Secondary Dilution: 1:5000
Image Submitted by: Nodar Makharashvili
University of Texas, Austin
Background publications Chen, Nievera, Lee et al.: "Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair." in: The Journal of biological chemistry, Vol. 283, Issue 12, pp. 7713-20, 2008 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN503204
289.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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