Coatomer Protein Complex, Subunit alpha (COPA) (Middle Region) antibody

Details for Product No. ABIN503275
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Antigen
Synonyms COPA, DDBDRAFT_0189693, DDBDRAFT_0233797, DDB_0189693, DDB_0233797, DKFZp469O221, AU040324, xenin, HEP-COP, cb281, fb13c12, wu:fb13c12
Epitope
Middle Region
(4), (2), (2), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Cow (Bovine), Xenopus laevis, Zebrafish (Danio rerio), Human, Chicken
(9), (3), (2), (1), (1), (1), (1)
Host
Rabbit
(7), (1), (1)
Clonality
Polyclonal
Application
Western Blotting (WB)
(9), (2), (2), (1), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN503275
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Immunogen Synthetic peptide directed towards the middle region of human COPA
Sequence IPKDADSQNP DAPEGKRSSG LTAVWVARNR FAVLDRMHSL LIKNLKNEIT
Predicted Reactivity Chicken : 100 %, Dog : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rat : 100 %, African clawed frog : 90 %, Bovine : 90 %, Zebrafish : 80 %
Characteristics This is a rabbit polyclonal antibody against COPA. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name COPA
Background In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms.In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms.
Molecular Weight 135 kDa
Gene ID 1314
NCBI Accession NM_004371, NP_004362
UniProt P53621
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 1224 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Coatomer Protein Complex, Subunit alpha (COPA) (Middle Region) antibody WB Suggested Anti-COPA Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:12500
Positive Control: 721_B cell lysate
Background publications Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Validation Images
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