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Details for Product No. ABIN503836

MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) (N-Term) antibody

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Antigen
Synonyms COCA2, FCC2, HNPCC, HNPCC2, hMLH1, 1110035C23Rik, AI317206, AI325952, AI561766, CG11482, Dmel\\CG11482, dmlh-1, dmlh1, zgc:66301, MLH1, LOC100232198
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Xenopus laevis, Dog (Canine), Pig (Porcine), Fruit Fly (Drosophila melanogaster), Human, Chicken
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN503836
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-MLH1 antibody: synthetic peptide directed towards the N terminal of human MLH1
Sequence MIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLD IVCERFTTSK
Predicted Reactivity African clawed frog : 100%, Dog : 100%, Horse : 100%, Human : 100%, Mouse : 100%, Pig : 100%, Rabbit : 100%, Rat : 100%, Bovine : 92%, Chicken : 85%, Zebrafish : 78%
Characteristics This is a rabbit polyclonal antibody against MLH1. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name MLH1
Background This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC.This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Alternatively spliced transcript variants encoding different isoforms have been described, but their full-length natures have not been determined.
Molecular Weight 84kDa
Gene ID 4292
NCBI Accession NP_000240, NM_000249
UniProt P40692
Research Area Cancer, DNA/RNA
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-MLH1 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Harley, Rosen, Risch et al.: "Ovarian cancer risk is associated with a common variant in the promoter sequence of the mismatch repair gene MLH1." in: Gynecologic oncology, Vol. 109, Issue 3, pp. 384-7, 2008 (PubMed).

Alternatives for antigen "MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1)", type "Antibodies"
Hosts (63), (37)
Reactivities (94), (35), (30), (14), (13), (8), (6), (1)
Applications (59), (32), (25), (15), (10), (9), (9), (8), (8), (6), (5), (3), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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