anti-MLH1 antibody (MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli)) (N-Term)

Details for Product anti-MLH1 Antibody No. ABIN503836, Supplier: Login to see New
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Antigen
Synonyms CG11482, Dmel\\CG11482, dmlh-1, dmlh1, zgc:66301, MLH1, LOC100232198, 1110035C23Rik, AI317206, AI325952, AI561766, COCA2, FCC2, HNPCC, HNPCC2, hMLH1
Alternatives
Epitope
N-Term
(24), (16), (13), (7), (7), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Chicken, Dog (Canine), Fruit Fly (Drosophila melanogaster), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus), Xenopus laevis
(149), (39), (38), (7), (5), (1), (1)
Host
Rabbit
(97), (54)
Clonality
Polyclonal
Conjugate
This MLH1 antibody is un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(106), (39), (38), (20), (19), (19), (13), (13), (11), (6), (3), (3), (2), (1), (1), (1), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the N terminal of human MLH1
Sequence MIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLD IVCERFTTSK
Predicted Reactivity African clawed frog : 100 %, Dog : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %, Bovine : 90 %, Chicken : 80 %, Zebrafish : 70 %
Characteristics This is a rabbit polyclonal antibody against MLH1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name MLH1 (MLH1 Antibody Abstract)
Background This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC.This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Alternatively spliced transcript variants encoding different isoforms have been described, but their full-length natures have not been determined.
Molecular Weight 84 kDa
Gene ID 4292
NCBI Accession NM_000249, NP_000240
UniProt P40692
Research Area Cancer, DNA/RNA
Pathways DNA Damage Repair
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 756 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-MLH1 antibody (MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli)) (N-Term) (ABIN503836) WB Suggested Anti-MLH1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: ...
Background publications Harley, Rosen, Risch et al.: "Ovarian cancer risk is associated with a common variant in the promoter sequence of the mismatch repair gene MLH1." in: Gynecologic oncology, Vol. 109, Issue 3, pp. 384-7, 2008 (PubMed).

Catalog No. ABIN503836
$289.00
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