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MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) (N-Term) antibody

Details for Product No. ABIN503836
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Antigen
Synonyms CG11482, Dmel\\CG11482, dmlh-1, dmlh1, zgc:66301, MLH1, LOC100232198, 1110035C23Rik, AI317206, AI325952, AI561766, COCA2, FCC2, HNPCC, HNPCC2, hMLH1
Epitope
N-Term
(17), (8), (5), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine), Rat (Rattus), Xenopus laevis, Dog (Canine), Pig (Porcine), Fruit Fly (Drosophila melanogaster), Human, Chicken
(98), (37), (33), (13), (13), (7), (5), (1)
Host
Rabbit
(72), (31)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(71), (30), (29), (17), (10), (10), (10), (9), (8), (6), (2)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN503836
289.00 $
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Immunogen Synthetic peptide directed towards the N terminal of human MLH1
Sequence MIENCLDAKSTSIQVIVKEGGLKLIQIQDNGTGIRKEDLD IVCERFTTSK
Predicted Reactivity African clawed frog : 100 %, Dog : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %, Bovine : 90 %, Chicken : 80 %, Zebrafish : 70 %
Characteristics This is a rabbit polyclonal antibody against MLH1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name MLH1
Background This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC.This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Alternatively spliced transcript variants encoding different isoforms have been described, but their full-length natures have not been determined.
Molecular Weight 84 kDa
Gene ID 4292
NCBI Accession NM_000249, NP_000240
UniProt P40692
Research Area Cancer, DNA/RNA
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 756 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-MutL Homolog 1, Colon Cancer, Nonpolyposis Type 2 (E. Coli) (MLH1) (N-Term) antibody WB Suggested Anti-MLH1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: Human Placenta
Background publications Harley, Rosen, Risch et al.: "Ovarian cancer risk is associated with a common variant in the promoter sequence of the mismatch repair gene MLH1." in: Gynecologic oncology, Vol. 109, Issue 3, pp. 384-7, 2008 (PubMed).

Validation Images
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