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IBTK antibody (C-Term)
IBTK
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-IBTK Antibody
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Target
See all IBTK Antibodies
IBTK
(Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK))
Binding Specificity
All epitopes for IBTK antibodies
C-Term
Reactivity
Human
Host
All hosts for IBTK antibodies
Rabbit
Clonality
All clonalities for IBTK antibodies
Polyclonal
Conjugate
All conjugates for IBTK antibodies
This IBTK antibody is un-conjugated
Application
All applications for IBTK antibodies
Western Blotting (WB)
Sequence
GDIFLKEEIN MEQNHSETMF KKAKTKAKKK PRKRSDSSGG YNLSDIIQSP
Characteristics
This is a rabbit polyclonal antibody against IBTK. It was validated on Western Blot.
Purification
Affinity purified
Immunogen
The immunogen is a synthetic peptide directed towards the C-terminal region of Human IBTK
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for IBTK
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Target
IBTK
(Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK))
Alternative Name
IBTK (IBTK Products )
Synonyms
IBTK antibody, fi40c08 antibody, wu:fi40c08 antibody, DKFZp468J085 antibody, BTBD26 antibody, BTKI antibody, RP1-93K22.1 antibody, 5430411K16Rik antibody, AA409502 antibody, mKIAA1417 antibody, inhibitor of Bruton tyrosine kinase antibody, inhibitor of Bruton agammaglobulinemia tyrosine kinase antibody, inhibitor of Bruton tyrosine kinase L homeolog antibody, IBTK antibody, ibtk antibody, Ibtk antibody, ibtk.L antibody
Background
Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Alias Symbols: IBTK, BTKI, KIAA1417, Protein Interaction Partner: IGSF8, CD81, LAMTOR3, ITK, BTK, AKT1, PRKD1, PRKCG, PRKCE, PRKCD, PRKCB, PRKCA, PLCG1, CUL3, PPP1CA, UBC, RGS2, Protein Size: 1353
Gene ID
25998
NCBI Accession
NP_056340
UniProt
Q9P2D0
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