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SPINT2 antibody (Internal Region)
SPINT2
Reactivity: Human, Cow, Dog
WB, EIA
Host: Goat
Polyclonal
unconjugated
Product Details anti-SPINT2 Antibody
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Target
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SPINT2
(serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2))
Binding Specificity
All epitopes for SPINT2 antibodies
Internal Region
Reactivity
All reactivities for SPINT2 antibodies
Human, Cow, Dog
Host
All hosts for SPINT2 antibodies
Goat
Clonality
All clonalities for SPINT2 antibodies
Polyclonal
Conjugate
All conjugates for SPINT2 antibodies
This SPINT2 antibody is un-conjugated
Application
All applications for SPINT2 antibodies
Western Blotting (WB), Enzyme Immunoassay (EIA)
Sequence
C-PSAPRRQDSE DH
Specificity
This antibody is expected to recognize both reported isoforms (NP_066925.1, NP_001159575.1).
Cross-Reactivity (Details)
Species reactivity (expected):Dog, Cow. Species reactivity (tested):Human.
Purification
Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.
Immunogen
Peptide with sequence from the internal region of the protein sequence according to NP_066925.1 and NP_001159575.1. Genename: SPINT2
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for SPINT2
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Target
SPINT2
(serine Peptidase Inhibitor, Kunitz Type, 2 (SPINT2))
Alternative Name
SPINT2 / HAI2 (SPINT2 Products )
Synonyms
HAI-2 antibody, Pb antibody, DIAR3 antibody, HAI2 antibody, Kop antibody, PB antibody, AL024025 antibody, C76321 antibody, serine peptidase inhibitor, Kunitz type, 2 antibody, serine peptidase inhibitor, Kunitz type 2 antibody, serine protease inhibitor, Kunitz type 2 antibody, Spint2 antibody, SPINT2 antibody
Background
HAI-2 (SPINT2) is a candidate tumour suppressor gene that is frequently hypermethylated and underexpressed in Human HCCs, and the KD-1 domain of HAI-2 is the key region responsible for its anti-invasive function. It is also implicated in Human cervical cancer. SPINT2 is an inhibitor of HGF activator. SPINT2 also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.Synonyms: HAI-2, Hepatocyte growth factor activator inhibitor type 2, Kunitz-type protease inhibitor 2, Placental bikunin
Gene ID
10653
NCBI Accession
NP_066925
UniProt
O43291
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