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MYD88 antibody (C-Term)
MYD88
Reactivity: Human, Mouse, Rat
WB, EIA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-MYD88 Antibody
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Target
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MYD88
(Myeloid Differentiation Primary Response Gene (88) (MYD88))
Binding Specificity
All epitopes for MYD88 antibodies
AA 279-296, C-Term
Reactivity
All reactivities for MYD88 antibodies
Human, Mouse, Rat
Host
All hosts for MYD88 antibodies
Rabbit
Clonality
All clonalities for MYD88 antibodies
Polyclonal
Conjugate
All conjugates for MYD88 antibodies
This MYD88 antibody is un-conjugated
Application
All applications for MYD88 antibodies
Western Blotting (WB), Enzyme Immunoassay (EIA)
Specificity
This antibody detects MYD88 at C-term.
Cross-Reactivity (Details)
Species reactivity (tested):Human, mouse, rat
Purification
Peptide affinity chromatography
Immunogen
MyD88 antibody was raised against a peptide corresponding to amino acids 279 to 296 of human MyD88, which are identical to those of mouse.
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
ELISA. Western blot. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Buffer
PBS containing 0.02 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Target Details for MYD88
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Target
MYD88
(Myeloid Differentiation Primary Response Gene (88) (MYD88))
Alternative Name
MYD88 (MYD88 Products )
Synonyms
MYD88D antibody, XMyD88 antibody, myd88d antibody, MGC84928 antibody, CG2078 antibody, DMMYD88 antibody, DmMyD88 antibody, DmMyd88 antibody, Dmel\\CG2078 antibody, EP(2)2535 antibody, Kra antibody, LD20892 antibody, MYD88 antibody, MyD88 antibody, Myd88F antibody, dMyD88 antibody, dMyd88 antibody, kra antibody, myd88 antibody, zgc:103541 antibody, GB12344 antibody, NV10640 antibody, myd88-a antibody, myd88-b antibody, myeloid differentiation primary response 88 antibody, myeloid differentiation primary response 88 S homeolog antibody, myeloid differentiation primary response gene 88 antibody, CG2078 gene product from transcript CG2078-RB antibody, myeloid differentiation primary response protein MyD88-A antibody, myeloid differentiation primary response protein MyD88 antibody, myeloid differentiation factor 88 antibody, myeloid differentiation primary response 88 L homeolog antibody, MYD88 antibody, myd88.S antibody, Myd88 antibody, myd88 antibody, LOC413194 antibody, LOC100118553 antibody, LOC575153 antibody, myd88.L antibody
Background
The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. Recently, MyD88 was identified as an adapter molecule in the IL-1 signaling pathway (1). MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-kappaB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor (2,3), which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.Synonyms: Myeloid differentiation primary response protein MyD88
Gene ID
4615
UniProt
Q99836
Pathways
NF-kappaB Signaling , TLR Signaling , Neurotrophin Signaling Pathway , Activation of Innate immune Response , Cellular Response to Molecule of Bacterial Origin , Positive Regulation of Immune Effector Process , Production of Molecular Mediator of Immune Response , Toll-Like Receptors Cascades
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