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DYRK1A antibody (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A) (AA 674-763)

Details for Product anti-DYRK1A Antibody No. ABIN560675, Supplier: Log in to see
Antigen
  • DYRK1A
  • dyrk
  • dyrk1
  • hp86
  • mnb
  • mnbh
  • DYRK
  • DYRK1
  • HP86
  • MNB
  • MNBH
  • MRD7
  • 2310043O08Rik
  • D16Ertd272e
  • D16Ertd493e
  • Dyrk
  • ENSMUSG00000074897
  • Gm10783
  • Mnbh
  • Mp86
  • mmb
  • PSK47
Epitope
AA 674-763, partial
36
25
15
15
11
3
3
2
2
2
1
1
1
1
1
1
Reactivity
Human
114
38
30
2
1
1
1
Host
Mouse
105
9
4
2
Clonality (Clone)
Monoclonal ()
Conjugate
This DYRK1A antibody is un-conjugated
8
8
8
7
7
7
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
101
68
11
8
8
7
4
4
3
2
2
Supplier
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Immunogen DYRK1A (NP_001387, 674 a.a. ~ 763 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen sequence: NQGNQAYQNR PVAANTLDFG QNGAMDVNLT VYSNPRQETG IAGHPTYQFS ANTGPAHYMT EGHLTMRQGA DREESPMTGV CVQQSPVASS
Clone 7D10
Isotype IgG2b kappa
Cross-Reactivity Human
Alternative Name DYRK1A (DYRK1A Antibody Abstract)
Background Full Gene Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Synonyms: DYRK,DYRK1,HP86,MNB,MNBH
Gene ID 1859
NCBI Accession NP_001387, NM_001396
Research Area Neurology, Neurogenesis
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Comment

Product Quality tested by: Antibody Reactive Against Recombinant Protein.

Restrictions For Research Use only
Buffer In 1x PBS, pH 7.4
Handling Advice Aliquot to avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store at -20 °C or lower. Aliquot to avoid repeated freezing and thawing.
Supplier Images
Western Blotting (WB) image for anti-DYRK1A antibody (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A) (AA 674-763) (ABIN560675) DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A express...
Western Blotting (WB) image for anti-DYRK1A antibody (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A) (AA 674-763) (ABIN560675) DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A express...
ELISA image for anti-DYRK1A antibody (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A) (AA 674-763) (ABIN560675) Detection limit for recombinant GST tagged DYRK1A is approximately 0.03ng/ml as a cap...
Western Blotting (WB) image for anti-DYRK1A antibody (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A) (AA 674-763) (ABIN560675) DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A express...
Western Blotting (WB) image for anti-DYRK1A antibody (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A) (AA 674-763) (ABIN560675) DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A express...
Western Blotting (WB) image for anti-DYRK1A antibody (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A) (AA 674-763) (ABIN560675) DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A express...
 image for anti-DYRK1A antibody (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A) (AA 674-763) (ABIN560675) Western Blot detection against Immunogen (35.53 KDa) .
Product cited in: Stringer, Abeysekera, Dria et al.: "Low dose EGCG treatment beginning in adolescence does not improve cognitive impairment in a Down syndrome mouse model." in: Pharmacology, biochemistry, and behavior, Vol. 138, pp. 70-9, 2015 (PubMed).

Blazek, Abeysekera, Li et al.: "Rescue of the abnormal skeletal phenotype in Ts65Dn Down syndrome mice using genetic and therapeutic modulation of trisomic Dyrk1a." in: Human molecular genetics, Vol. 24, Issue 20, pp. 5687-96, 2015 (PubMed).

Najas, Arranz, Lochhead et al.: "DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome." in: EBioMedicine, Vol. 2, Issue 2, pp. 120-34, 2015 (PubMed).

Thompson, Bhansali, Diebold et al.: "DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3." in: The Journal of experimental medicine, Vol. 212, Issue 6, pp. 953-70, 2015 (PubMed).

Grau, Arató, Fernández-Fernández et al.: "DYRK1A-mediated phosphorylation of GluN2A at Ser(1048) regulates the surface expression and channel activity of GluN1/GluN2A receptors." in: Frontiers in cellular neuroscience, Vol. 8, pp. 331, 2014 (PubMed).

García-Cerro, Martínez, Vidal et al.: "Overexpression of Dyrk1A is implicated in several cognitive, electrophysiological and neuromorphological alterations found in a mouse model of Down syndrome." in: PLoS ONE, Vol. 9, Issue 9, pp. e106572, 2014 (PubMed).

Janel, Sarazin, Corlier et al.: "Plasma DYRK1A as a novel risk factor for Alzheimer's disease." in: Translational psychiatry, Vol. 4, pp. e425, 2014 (PubMed).

Souchet, Latour, Gu et al.: "Molecular rescue of DYRK1A overexpression in cystathionine beta synthase-deficient mouse brain by enriched environment combined with voluntary exercise." in: Journal of molecular neuroscience : MN, Vol. 55, Issue 2, pp. 318-23, 2015 (PubMed).

Rachdi, Kariyawasam, Guez et al.: "Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass." in: Diabetologia, Vol. 57, Issue 5, pp. 960-9, 2014 (PubMed).

Thomazeau, Lassalle, Iafrati et al.: "Prefrontal deficits in a murine model overexpressing the down syndrome candidate gene dyrk1a." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 4, pp. 1138-47, 2014 (PubMed).

Hibaoui, Grad, Letourneau et al.: "Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21." in: EMBO molecular medicine, Vol. 6, Issue 2, pp. 259-77, 2014 (PubMed).

Fant, Durieu, Chicanne et al.: "cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease." in: Molecular pharmacology, Vol. 85, Issue 3, pp. 441-50, 2014 (PubMed).

Pons-Espinal, Martinez de Lagran, Dierssen: "Environmental enrichment rescues DYRK1A activity and hippocampal adult neurogenesis in TgDyrk1A." in: Neurobiology of disease, Vol. 60, pp. 18-31, 2013 (PubMed).

Stefos, Soppa, Dierssen et al.: "NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect." in: PLoS ONE, Vol. 8, Issue 6, pp. e67470, 2013 (PubMed).

Laguna, Barallobre, Marchena et al.: "Triplication of DYRK1A causes retinal structural and functional alterations in Down syndrome." in: Human molecular genetics, Vol. 22, Issue 14, pp. 2775-84, 2013 (PubMed).

Tlili, Jacobs, de Koning et al.: "Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic Akt/GSK3 pathways in hyperhomocysteinemic mice." in: Biochimica et biophysica acta, Vol. 1832, Issue 6, pp. 718-28, 2013 (PubMed).

Arque, Casanovas, Dierssen: "Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: possible role in Down syndrome." in: PLoS ONE, Vol. 8, Issue 1, pp. e54285, 2013 (PubMed).

Altafaj, Martín, Ortiz-Abalia et al.: "Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome." in: Neurobiology of disease, Vol. 52, pp. 117-27, 2013 (PubMed).

Spellman, Ahmed, Dubach et al.: "Expression of trisomic proteins in Down syndrome model systems." in: Gene, Vol. 512, Issue 2, pp. 219-25, 2012 (PubMed).

Lilienthal, Kolanowski, Becker: "Development of a sensitive non-radioactive protein kinase assay and its application for detecting DYRK activity in Xenopus laevis oocytes." in: BMC biochemistry, Vol. 11, pp. 20, 2010 (PubMed).

Scott, Berger, McKean: "The role of atmospheric pressure variation in the development of spontaneous pneumothoraces." in: The American review of respiratory disease, Vol. 139, Issue 3, pp. 659-62, 1989 (PubMed).