ALDH5A1 antibody (Internal Region)

Catalog No. ABIN569594

Product Details anti-ALDH5A1 Antibody

Target: ALDH5A1 (Aldehyde Dehydrogenase 5 Family, Member A1 (ALDH5A1))

Binding Specificity: AA 485-496, Internal Region

Reactivity: Human, Rat, Mouse, Cow, Dog

Host: Goat

Clonality: Polyclonal

Conjugate: This ALDH5A1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Sequence: C-SQDPAQIWRV AE

Specificity: This antibody is expected to recognize both reported isoforms (NP_733936.1, NP_001071.1).

Cross-Reactivity (Details): Species reactivity (expected):Bovine.
Species reactivity (tested):Human, Mouse, Rat.

Purification: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the internal region of Human ALDH5A1.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for ALDH5A1

Target: ALDH5A1 (Aldehyde Dehydrogenase 5 Family, Member A1 (ALDH5A1))

Alternative Name: ALDH5A1 / SSADH (ALDH5A1 Products)

Synonyms: SSADH antibody, SSDH antibody, Ssadh antibody, 6330403E24Rik antibody, Ahd-1 antibody, Ahd1 antibody, D630032B01Rik antibody, OTTMUSG00000000613 antibody, Ssdh1 antibody, aldehyde dehydrogenase 5 family member A1 antibody, aldehyde dehydrogenase 5 family, member A1 antibody, aldhehyde dehydrogenase family 5, subfamily A1 antibody, ALDH5A1 antibody, aldh5a1 antibody, Aldh5a1 antibody

Background: Defects in ALDH5A1 are the cause of succinate semialdehyde dehydrogenase deficiency (SSADH deficiency) [MIM:271980]. SSADH deficiency is a rare inborn error in the metabolism of 4-aminobutyric acid (GABA) which leads to accumulation of 4-hydroxybutyric acid in physiologic fluids of patients. The disease is characterized by severe ataxia and by mildly retarded psychomotor development.Synonyms: Aldehyde dehydrogenase family 5 member A1, NAD(+)-dependent succinic semialdehyde dehydrogenase, Succinate-semialdehyde dehydrogenase, mitochondrial

Molecular Weight: 58.7kDa (NP_733936.1).

Gene ID: 7915

NCBI Accession: NP_001071

UniProt: P51649

Pathways: Monocarboxylic Acid Catabolic Process