CD46 antibody (PE)

Catalog No. ABIN610111

This Mouse Monoclonal antibody specifically detects CD46 in WB, FACS and Func. It exhibits reactivity toward Human and has been mentioned in 3+ publications.

Quick Overview for CD46 antibody (PE) (ABIN610111)

Target: CD46

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD46 antibody is conjugated to PE

Application: Western Blotting (WB), Flow Cytometry (FACS), Functional Studies (Func)

Clone: 169-1-EA-3

Product Details anti-CD46 Antibody (PE)

Specificity: SCR1 epitope of CD46.

Purification: Gel filtration

Immunogen: Human PBL and EBV transformed LCL.

Isotype: IgG2a

Application Details

Application Notes: Approved: Flo, Func, WB

Usage: Function: Does not block MCP function. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 50 mM sodium phosphate,  pH 7.5, 500 mM potassium chloride, 150 mM sodium chloride, 15 % Glycerol, 0.2 % BSA, 0.04 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze. Product is photosensitive and should be protected from light.

Storage: 4 °C

Storage Comment: Store at 4°C. Do not freeze. Protect from light.

References for anti-CD46 antibody (PE) (ABIN610111)

Saucier, Papavasiliou, Palazzo, Naujokas, Kremer, Park: "Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis." in: Oncogene, Vol. 21, Issue 12, pp. 1800-11, (2002) (PubMed).

Elowe, Holland, Kulkarni, Pawson: "Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction." in: Molecular and cellular biology, Vol. 21, Issue 21, pp. 7429-41, (2001) (PubMed).

Miki, Miura, Matuoka, Nakata, Hirokawa, Orita, Kaibuchi, Takai, Takenawa: "Association of Ash/Grb-2 with dynamin through the Src homology 3 domain." in: The Journal of biological chemistry, Vol. 269, Issue 8, pp. 5489-92, (1994) (PubMed).

Target Details for CD46

Target: CD46

Alternative Name: MCP / CD46

Background: Name/Gene ID: CD46

Synonyms: CD46, AHUS2, CD46 antigen, MCP, Measles virus receptor, TLX, MIC10, TRA2.10, Membrane cofactor protein

Gene ID: 4179

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization