CTNNB1 antibody (Catenin (Cadherin-Associated Protein), beta 1, 88kDa)

Details for Product anti-CTNNB1 Antibody No. ABIN614788, Supplier: Log in to see
Antigen
  • Jup
  • LOC100217813
  • CTNNB1
  • CTNNB
  • Bfc
  • Catnb
  • Mesc
  • ctnnb
  • id:ibd2058
  • wu:fb73e10
  • wu:fi81c06
  • wu:fk25h01
  • ctnnb1
  • CHBCAT
  • MRD19
  • armadillo
  • beta-catenin
  • catenin (cadherin-associated protein), beta 1, 88kDa
  • catenin (cadherin associated protein), beta 1
  • catenin (cadherin-associated protein), beta 1
  • CTNNB1
  • LOC100217813
  • Ctnnb1
  • ctnnb1
  • ctnnb1-a
  • ctnnb1-b
Alternatives
anti-Human CTNNB1 antibody for Enzyme Immunoassay
Reactivity
Hamster, Human, Mouse (Murine)
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223
198
63
53
41
26
25
21
21
15
15
14
10
9
9
3
1
1
1
1
1
1
Host
Mouse
310
193
9
2
Clonality (Clone)
Monoclonal ()
Conjugate
This CTNNB1 antibody is un-conjugated
14
11
8
8
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6
4
4
4
4
2
2
2
2
2
2
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
443
154
126
123
113
111
69
31
16
13
8
8
4
4
3
3
2
2
1
Options
Supplier
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Supplier Product No.
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Immunogen Recombinant human beta-catenin
Clone EM-22
Isotype IgG1
Specificity This antibody reacts with C-terminal part of beta-Catenin, an 88 kDa multifunctional protein involved both in cell adhesion and in activation of transcription.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Hamster.
Species reactivity (tested):Human.
Purification Protein-A Affinity Chromatography
Alternative Name Catenin beta-1 (CTNNB1 Antibody Abstract)
Background Beta-catenin is a multifunctional protein involved both in cell adhesion and in activation of transcription. Calcium-dependent intercellular adhesion transmembrane glycoprotein E-cadherin interacts by its cytoplasmic domain with reciprocally bound alpha, beta and gamma catenin. Beta-catenin links this complex through alpha-actinin to the cytoskeleton. Functional cadherin-catenin system is important for invasiveness of tumour cells. Beta-catenin level in cytoplasm is controlled by glycogen synthase kinase-3 beta. When activity of this kinase is blocked (e.g. by excessive stimulation of Wnt signaling pathway), hypophosphorylated stable form of beta-catenin accumulates in the cytoplasm, translocates to the nucleus and activates transcription of genes including those that are involved in cell cycle control. As a result, cell division and neoplastic transformation are promoted.Synonyms: Beta-catenin, CTNNB, CTNNB1
Gene ID 1499
NCBI Accession NP_001091679
UniProt P35222
Research Area Signaling
Pathways WNT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Tube Formation, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS, pH ~7.4, 15 mM Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunofluorescence (IF) image for anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibody (ABIN614788) anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibody
Western Blotting (WB) image for anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibody (ABIN614788) anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibody (Image 2)
Flow Cytometry (FACS) image for anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibody (ABIN614788) anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibody (Image 3)
Background publications Nowak, Madej, Dziegiel: "Expression of E-cadherin, beta-catenin and Ki-67 antigen and their reciprocal relationships in mammary adenocarcinomas in bitches." in: Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society, Vol. 45, Issue 3, pp. 233-8, 2007 (PubMed).

Jung, Chung, Kim, Kim, Heo, Ahn, Hwang, Kim, Lee, Kim, Kim, Chang: "Epstein-Barr virus, beta-catenin, and E-cadherin in gastric carcinomas." in: Journal of Korean medical science, Vol. 22, Issue 5, pp. 855-61, 2007 (PubMed).

Valenta, Lukas, Korinek: "HMG box transcription factor TCF-4's interaction with CtBP1 controls the expression of the Wnt target Axin2/Conductin in human embryonic kidney cells." in: Nucleic acids research, Vol. 31, Issue 9, pp. 2369-80, 2003 (PubMed).

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