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Plakophilin 2 antibody (Internal Region)
PKP2
Reactivity: Human, Rat, Mouse, Dog, Cow
WB, EIA
Host: Goat
Polyclonal
unconjugated
Product Details anti-Plakophilin 2 Antibody
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Target
See all Plakophilin 2 (PKP2) Antibodies
Plakophilin 2 (PKP2)
Binding Specificity
All epitopes for Plakophilin 2 antibodies
AA 125-139, Internal Region
Reactivity
All reactivities for Plakophilin 2 antibodies
Human, Rat, Mouse, Dog, Cow
Host
All hosts for Plakophilin 2 antibodies
Goat
Clonality
All clonalities for Plakophilin 2 antibodies
Polyclonal
Conjugate
All conjugates for Plakophilin 2 antibodies
This Plakophilin 2 antibody is un-conjugated
Application
All applications for Plakophilin 2 antibodies
Western Blotting (WB), Enzyme Immunoassay (EIA)
Sequence
C-RGTAQYSSQK SVEER
Specificity
This antibody is expected to recognize both reported isoforms (NP_001005242.2, NP_004563.2).
Cross-Reactivity (Details)
Species reactivity (expected):Human, Canine (Dog), Cow. Species reactivity (tested):Mouse and Rat.
Purification
Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.
Immunogen
Peptide with sequence from the internal region of the protein sequence according to NP_001005242.2, NP_004563.2. Genename: PKP2
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for Plakophilin 2
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Target
Plakophilin 2 (PKP2)
Alternative Name
Plakophilin-2 (PKP2 Products )
Synonyms
ARVD9 antibody, 1200008D14Rik antibody, 1200012P04Rik antibody, AA516617 antibody, Pkp2l antibody, plakophilin 2 antibody, PKP2 antibody, Pkp2 antibody
Background
Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly and regulation of cell migration. Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin 4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function.Synonyms: PKP2
Gene ID
5318
NCBI Accession
NP_004563
UniProt
Q99959
Pathways
Cell-Cell Junction Organization , SARS-CoV-2 Protein Interactome , The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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