SMPD3 antibody

Catalog No. ABIN635767

Product Details anti-SMPD3 Antibody

Target: SMPD3 (Sphingomyelin Phosphodiesterase 3 (SMPD3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMPD3 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity purified

Immunogen: SMPD3 antibody was raised using a synthetic peptide corresponding to a region with amino acids RPPEADDPVPGGQARNGAGGGPRGQTPNHNQQDGDSGSLGSPSASRESLV

Application Details

Application Notes: WB: 1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

SMPD3 Blocking Peptide, catalog no. 33R-8099, is also available for use as a blocking control in assays to test for specificity of this SMPD3 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Lyophilized powder. Add distilled water for a 1 mg/mL concentration of SMPD3 antibody in PBS

Concentration: Lot specific

Buffer: PBS

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.

Target Details for SMPD3

Target: SMPD3 (Sphingomyelin Phosphodiesterase 3 (SMPD3))

Alternative Name: SMPD3 (SMPD3 Products)

Synonyms: 4631433G07Rik antibody, AI427456 antibody, AW537966 antibody, fro antibody, nSMase2 antibody, cca1 antibody, NSMASE2 antibody, sphingomyelin phosphodiesterase 3 antibody, sphingomyelin phosphodiesterase 3, neutral antibody, SMPD3 antibody, Smpd3 antibody

Background: SMPD3 catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. SMPD3 regulates the cell cycle by acting as a growth suppressor in confluent cells. It probably acts as a regulator of postnatal development and participates in bone and dentin mineralization.

Molecular Weight: 71 kDa (MW of target protein)

Pathways: Hormone Transport