TRAIL antibody

Catalog No. ABIN640733

Product Details anti-TRAIL Antibody

Target: TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRAIL antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit Anti-Human CD253

Specificity: DS-PB-02541 is specific for human CD253, otherwise known as TRAIL or Apo2L, a 281 amino acid type II transmembrane glycoprotein and member of the tumor necrosis factor superfamily, which induces apoptosis in tumor and transformed cells, but not normal cells. Activation of apoptosis by CD253 occurs through binding to the death-signaling receptors DR4 (TRAILR1) and DR5 (TRAILR2), leading to formation of the death-inducing signaling complex (DISC) and the triggering of a proteolytic caspase cascade. There are however decoy receptors known as DcR1 (TRAILR3) and DcR2 (TRAILR4) which competitively bind to CD253 and are unable to initiate apoptosis. CD253 also plays a role in immune surveillance, acting as a mediator of monocyte, NK cell, dendritic cell and T cell anti-tumor and anti-viral cytotoxicity.

Characteristics: Adhesion Molecule/Cell Surface

Purification: Purified

Immunogen: Antisera to human CD253 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.

Isotype: IgG

Application Details

Application Notes: ELISA (dilution: 0.1, 0.2 μg/mL), Immunohistology - Paraffin, Western Blotting

Restrictions: For Research Use only

Handling

Reconstitution: Reconstitute with 0.1 mL distilled water. For long term storage the addition of 0.09 % sodium azide is recommended.

Concentration: IgG concentration 1.0 mg/ml after reconstitution

Buffer: Phosphate buffered saline pH7.4

Storage: -20 °C

Storage Comment: -20°C

Target Details for TRAIL

Target: TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))

Alternative Name: CD253 (TNFSF10 Products)

Synonyms: APO2L antibody, Apo-2L antibody, CD253 antibody, TL2 antibody, TRAIL antibody, A330042I21Rik antibody, AI448571 antibody, APO-2L antibody, Ly81 antibody, Trail antibody, tl2 antibody, apo2l antibody, cd253 antibody, trail antibody, apo-2l antibody, trail1 antibody, xtrail1 antibody, tnfsf10l2 antibody, zgc:92320 antibody, TNLG6A antibody, TNF superfamily member 10 antibody, tumor necrosis factor (ligand) superfamily, member 10 antibody, tumor necrosis factor superfamily member 10 antibody, TNF superfamily member 10 S homeolog antibody, TNFSF10 antibody, Tnfsf10 antibody, tnfsf10.S antibody, tnfsf10 antibody

Pathways: Apoptosis, Positive Regulation of Endopeptidase Activity