MUC1 antibody

Catalog No. ABIN643712

Product Details anti-MUC1 Antibody

Target: MUC1 (Mucin 1 (MUC1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MUC1 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Purpose: Mouse Anti-Human Mucin 1

Specificity: Mucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by many epithelial tissues in vertebrates. DS-MB-01935 recognizes CD227, also known as mucin 1 which is a breast cancer associated mucin encoded by the Muc-1 gene. CD227 is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. This protein is overexpressed abundantly in >90% breast carcinomas and metastases. The dominant epitope recognized by this antibody is the 12-mer GVTSAPDTRPAP of the mucin 1 tandem repeat. DS-MB-01935 has been tested on frozen human ovarian carcinoma tissue sections and paraffin embedded sections from normal breast tissue. This antibody also reacts weakly with sections of small intestine and colon.

Purification: Purified

Immunogen: Human breast cancer cell line ZR-75-1.

Isotype: IgG1

Application Details

Application Notes: Immunohistology - Frozen, Flow Cytometry, Immunoprecipitation, Immunohistology - Paraffin

Restrictions: For Research Use only

Handling

Concentration: IgG concentration 1.0 mg/ml

Buffer: Phosphate buffered saline

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C

Target Details for MUC1

Target: MUC1 (Mucin 1 (MUC1))

Alternative Name: CD227 (MUC1 Products)

Synonyms: CA 15-3 antibody, CD227 antibody, EMA antibody, H23AG antibody, KL-6 antibody, MAM6 antibody, MCKD1 antibody, MUC-1 antibody, MUC-1/SEC antibody, MUC-1/X antibody, MUC1/ZD antibody, PEM antibody, PEMT antibody, PUM antibody, Muc-1 antibody, mucin 1, cell surface associated antibody, mucin 1, transmembrane antibody, MUC1 antibody, Muc1 antibody

Pathways: Negative Regulation of intrinsic apoptotic Signaling