NGFR antibody

Catalog No. ABIN644003

Product Details anti-NGFR Antibody

Target: NGFR (Nerve Growth Factor Receptor (NGFR))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NGFR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Purpose: Rabbit Anti-Human CD271

Specificity: DS-PB-00434 recognises CD271, a transmembrane protein of 70-75kDa, otherwise known as Nerve Growth Factor Receptor (NGFR). It is a pro-apoptotic member of the tumor necrosis factor receptor (TNFR) family and its ligands include NGF, brain derived growth neurotrophic factor (BDNF), NT3 and NT4. CD271 has been shown to interact with tropomyosin-receptor-kinase A (TrkA) forming the high-affinity NGF receptor, while CD271 can signal alone, constituting the low-affinity NGF receptor. When signaling alone, CD271 is involved in apoptosis, neurite outgrowth during development and myelination. Mutations and changes in CD271 expression have been implicated in various pathological diseases including Alzheimer's Disease, cerebral oedema and retinoblastoma. Western BlotDetects a band of approximately 75-80kDa in A-20 cell lysate.

Cross-Reactivity: Mouse (Murine)

Characteristics: Adhesion Molecule/Cell Surface

Purification: Purified

Immunogen: Antisera to CD271 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.

Isotype: IgG

Application Details

Application Notes: Immunohistology - Frozen, Western Blotting

Restrictions: For Research Use only

Handling

Concentration: IgG concentration 1.0 mg/ml

Buffer: Phosphate buffered saline

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C

References for anti-NGFR antibody (ABIN644003)

Frank, Schatton, Kim, Zhan, Wilson, Ma, Saab, Osherov, Widlund, Gasser, Waaga-Gasser, Kupper, Murphy, Frank: "VEGFR-1 expressed by malignant melanoma-initiating cells is required for tumor growth." in: Cancer research, Vol. 71, Issue 4, pp. 1474-85, (2011) (PubMed).

Target Details for NGFR

Target: NGFR (Nerve Growth Factor Receptor (NGFR))

Alternative Name: CD271 (NGFR Products)

Synonyms: ngfr antibody, wu:fb38c02 antibody, wu:fc10h01 antibody, CD271 antibody, Gp80-LNGFR antibody, TNFRSF16 antibody, p75(NTR) antibody, p75NTR antibody, LNGFR antibody, RNNGFRR antibody, Tnfrsf16 antibody, p75 antibody, NRH1b antibody, fullback antibody, nrh1 antibody, p75ntr antibody, tnfrsf16 antibody, p75NGFR antibody, nerve growth factor receptor antibody, neurotrophin receptor associated death domain antibody, nerve growth factor receptor S homeolog antibody, nerve growth factor receptor (TNFR superfamily, member 16) antibody, NGFR antibody, nradd antibody, Ngfr antibody, ngfr.S antibody

Pathways: NF-kappaB Signaling, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding