DS-PB-01970 is specific for mouse Toll-like receptor 7 (TLR7). TLR7 is thought to play a role in the innate immune response to viral pathogens. Mouse TLR7 is localized in endosomal compartments, and recognises single stranded RNA viruses. Stimulation of TLR7 causes a type I IFN response, in a MyD88 dependent pathway.
Cross-Reactivity
Human
Purification
Purified
Immunogen
Antisera to mouse TLR7 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by ion exchange chromatography.