SYVN1 antibody (N-Term)
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- Target See all SYVN1 Antibodies
- SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))
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Binding Specificity
- AA 106-138, N-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SYVN1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Predicted Reactivity
- M, X
- Purification
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Immunogen
- This HRD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-138 amino acids from the N-terminal region of human HRD1.
- Clone
- RB15288
- Isotype
- Ig Fraction
- Top Product
- Discover our top product SYVN1 Primary Antibody
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- Application Notes
- WB: 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Expiry Date
- 6 months
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Grp94 Protein Delivers γ-Aminobutyric Acid Type A (GABAA) Receptors to Hrd1 Protein-mediated Endoplasmic Reticulum-associated Degradation." in: The Journal of biological chemistry, Vol. 291, Issue 18, pp. 9526-39, (2016) (PubMed).
: "TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 31, pp. 11425-30, (2014) (PubMed).
: "Enhanced endoplasmic reticulum entry of tumor antigen is crucial for cross-presentation induced by dendritic cell-targeted vaccination." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 12, pp. 6010-21, (2013) (PubMed).
: "MHC class I molecules are preferentially ubiquitinated on endoplasmic reticulum luminal residues during HRD1 ubiquitin E3 ligase-mediated dislocation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 35, pp. 14290-5, (2013) (PubMed).
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Grp94 Protein Delivers γ-Aminobutyric Acid Type A (GABAA) Receptors to Hrd1 Protein-mediated Endoplasmic Reticulum-associated Degradation." in: The Journal of biological chemistry, Vol. 291, Issue 18, pp. 9526-39, (2016) (PubMed).
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- Target
- SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))
- Alternative Name
- HRD1 (SYVN1 Products)
- Synonyms
- DER3 antibody, HRD1 antibody, hrd1 antibody, 1200010C09Rik antibody, AW211966 antibody, C85322 antibody, D530017H19Rik antibody, Hrd1 antibody, RGD1310488 antibody, syvn1 antibody, syvn1-a antibody, syvn1-b antibody, wu:fk91f10 antibody, zgc:55735 antibody, zgc:77108 antibody, synoviolin 1 antibody, synovial apoptosis inhibitor 1, synoviolin antibody, synoviolin 1 S homeolog antibody, SYVN1 antibody, syvn1 antibody, Syvn1 antibody, syvn1.S antibody
- Background
- HRD1 encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. This gene and the mitochondrial ribosomal protein L49 gene use in their respective 3' UTRs some of the same genomic sequence.
- Molecular Weight
- 67685
- NCBI Accession
- NP_115807, NP_757385
- UniProt
- Q86TM6
- Pathways
- ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling
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