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Details for Product No. ABIN650861

Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) (AA 149-175), (cleaved), (Asp175) antibody

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Antigen
Synonyms
xcpp32, Lice, CPP32, SCA-1, CPP32B, CC3, CG14902, Cas3, Casp 3, Casp3, Caspase-3, DECAY, Decay, Dmel\\CG14902, Drosophila executioner caspase related to Apopain/Yama, caspase 3, caspase-3, CG7788, DRI ... show more
Epitope
»Alternatives AA 149-175, cleaved, Asp175
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Dot Blot (DB), Immunohistochemistry (IHC)
Pubmed 1 reference available
Catalog no. ABIN650861
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This Cleaved antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-175 AA from human Cleaved.
Clone RB25833
Isotype Ig
Specificity This Cleaved-CASP3 (Asp175) antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between 155~184 amino acids surrounding Asp175 of human CASP3.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Pig (Porcine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CASP3
Background CASP3 encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
Synonyms: Caspase-3 subunit p12, Caspase-3 subunit p17, SREBP cleavage activity 1, SCA-1, Protein Yama, Cysteine protease CPP32, CPP-32, Apopain, Caspase-3, CASP-3,CPP32, CASP3
Molecular Weight 31608 DA
Gene ID 836
UniProt P42574
Research Area Apoptosis/Necrosis, Signaling, Phospho-specific antibodies, Protein Modifications, Metabolism, Cell Structure
Application Notes Recommend dilutions: DB : 1:500,IHC : 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Mei, Yong, Liu et al.: "tRNA binds to cytochrome c and inhibits caspase activation." in: Molecular cell, Vol. 37, Issue 5, pp. 668-78, 2010 (PubMed).

Alternatives for antigen "Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3)", type "Antibodies"
Hosts (232), (58), (7), (2)
Reactivities (275), (94), (84), (25), (23), (22), (9), (9), (8), (7), (6), (6), (5), (4), (3), (1), (1), (1), (1), (1)
Applications (242), (100), (79), (78), (63), (17), (16), (15), (12), (11), (10), (6), (4), (3), (2), (2), (2), (1)
Conjugates (11), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (31), (19), (13), (13), (8), (8), (6), (5), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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