Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) (AA 149-175), (cleaved), (Asp175) antibody

Details for Product No. ABIN650861
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

 
Antigen
Synonyms
xcpp32, Lice, CPP32, SCA-1, CPP32B, CC3, CG14902, Cas3, Casp 3, Casp3, Caspase-3, DECAY, Decay, Dmel\\CG14902, Drosophila executioner caspase related to Apopain/Yama, caspase 3, caspase-3, CG7788, DRI ... show more
xcpp32, Lice, CPP32, SCA-1, CPP32B, CC3, CG14902, Cas3, Casp 3, Casp3, Caspase-3, DECAY, Decay, Dmel\\CG14902, Drosophila executioner caspase related to Apopain/Yama, caspase 3, caspase-3, CG7788, DRICE, Dmel\\CG7788, DrICE, DrIce, Drice, ICE, crice, drICE, drIce, drice, ice show less
Epitope
AA 149-175, cleaved, Asp175
(24), (20), (14), (13), (12), (10), (7), (7), (6), (6), (4), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(279), (104), (90), (20), (18), (17), (5), (5), (4), (4), (4), (3), (2), (2), (2), (1)
Host
Rabbit
(249), (54), (7), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(10), (5), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Dot Blot (DB), Immunohistochemistry (IHC)
(254), (95), (94), (90), (52), (22), (15), (14), (14), (12), (10), (4), (4), (2), (2), (2), (1)
Pubmed 1 reference available
Catalog no. ABIN650861
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This Cleaved antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-175 AA from human Cleaved.
Clone RB25833
Isotype Ig
Specificity This Cleaved-CASP3 (Asp175) antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between 155~184 amino acids surrounding Asp175 of human CASP3.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Pig (Porcine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CASP3
Background CASP3 encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
Synonyms: Caspase-3 subunit p12, Caspase-3 subunit p17, SREBP cleavage activity 1, SCA-1, Protein Yama, Cysteine protease CPP32, CPP-32, Apopain, Caspase-3, CASP-3,CPP32, CASP3
Molecular Weight 31608 DA
Gene ID 836
UniProt P42574
Research Area Apoptosis/Necrosis, Signaling, Phospho-specific antibodies, Protein Modifications, Metabolism, Cell Structure
Application Notes DB = 1:500, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) (AA 149-175), (cleaved), (Asp175) antibody Dot blot analysis of anti-Cleaved-CASP3 (Asp175) Antibody (ABIN650861) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL.
anti-Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) (AA 149-175), (cleaved), (Asp175) antibody (2) Cleaved-CASP3 (Asp175)Antibody (ABIN650861) IHC analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining
Background publications Mei, Yong, Liu et al.: "tRNA binds to cytochrome c and inhibits caspase activation." in: Molecular cell, Vol. 37, Issue 5, pp. 668-78, 2010 (PubMed).

Hosts (249), (54), (7), (2)
Reactivities (279), (104), (90), (20), (18), (17), (5), (5), (4), (4), (4), (3), (2), (2), (2), (1)
Applications (254), (95), (94), (90), (52), (22), (15), (14), (14), (12), (10), (4), (4), (2), (2), (2), (1)
Conjugates (10), (5), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (24), (20), (14), (13), (12), (10), (7), (7), (6), (6), (4), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
back to top