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MST1R antibody (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase))

Details for Product anti-MST1R Antibody No. ABIN652379, Supplier: Log in to see
Antigen
  • CD136
  • CDw136
  • PTK8
  • RON
  • Fv-2
  • Fv2
  • Ron
  • STK
  • Cdw136
  • Ptk8
  • Stk
Alternatives
anti-Human MST1R antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Human
170
65
35
1
1
1
1
Host
Rabbit
166
20
4
Clonality (Clone)
Polyclonal ()
Conjugate
This MST1R antibody is un-conjugated
12
12
10
10
8
8
5
2
2
2
2
2
2
2
2
1
1
Application
Western Blotting (WB)
98
91
30
27
25
2
2
2
1
1
1
Supplier
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Immunogen This RON antibody is generated from rabbits immunized with RON recombinant protein.
Clone RB22857
Isotype Ig
Specificity This RON antibody is generated from rabbits immunized with RON recombinant protein between amino acids 163-514.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name RON (MST1R Antibody Abstract)
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
Synonyms: p185-Ron, CDW136, CD136 antigen, MST1R, RON, Macrophage-stimulating protein receptor alpha chain, Macrophage-stimulating protein receptor beta chain, Macrophage-stimulating protein receptor MSPR, MSP receptor
Molecular Weight 152227 DA
Gene ID 4486
UniProt Q04912
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Metabolism, Cell Structure
Pathways RTK Signaling
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.32 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-MST1R antibody (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase)) (ABIN652379) Western blot analysis of RON Antibody (ABIN652379) in HL-60 cell line lysates (35 µg/...
Background publications Penengo, Rubin, Yarden et al.: "c-Cbl is a critical modulator of the Ron tyrosine kinase receptor." in: Oncogene, Vol. 22, Issue 24, pp. 3669-79, 2003 (PubMed).

Danilkovitch-Miagkova, Duh, Kuzmin et al.: "Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 8, pp. 4580-5, 2003 (PubMed).

Zhou, He, Chen et al.: "Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential." in: Oncogene, Vol. 22, Issue 2, pp. 186-97, 2003 (PubMed).