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CDC14 Cell Division Cycle 14 Homolog A (S. Cerevisiae) (CDC14A) (AA 1-379) antibody

Details for Product No. ABIN652436
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Antigen
Synonyms xcdc14a, A830059A17Rik, CDC14A2, CDC14a1, Cdc14, cdc14, hCDC14
Epitope
AA 1-379
(10), (9), (7), (6), (3), (3), (2), (1), (1)
Reactivity
Human, Mouse (Murine)
(55), (16), (15), (12), (12)
Host
Rabbit
(37), (15), (3)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(44), (30), (10), (9), (7), (7), (5), (3), (2), (1)
Pubmed 4 references available
Quantity 400 µL
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Catalog No. ABIN652436
291.50 $
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Immunogen This Cdc14 antibody is generated from rabbits immunized with a recombinant protein encoding aa 1-379 of human cdc14.
Clone RB7269
Isotype Ig
Specificity This Cdc14 antibody is generated from rabbits immunized with a recombinant protein encoding aa 1~379 of human cdc14.
Purification This antibody is purified through a protein A column, followed by dialysis against PBS.
Alternative Name Cdc14
Background The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.
Synonyms: CDC14 cell division cycle 14 homolog A
Molecular Weight 66574 DA
Gene ID 8556
UniProt NP_003663
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-CDC14 Cell Division Cycle 14 Homolog A (S. Cerevisiae) (CDC14A) (AA 1-379) antibody His6-cdc14 Antibody (ABIN652436) western blot analysis in HepG2 cell line lysates (35 µg/lane).This demonstrates the cdc14 antibody detected the cdc14 protein (arrow).
anti-CDC14 Cell Division Cycle 14 Homolog A (S. Cerevisiae) (CDC14A) (AA 1-379) antibody (2) Cdc14 Antibody (ABIN652436)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Background publications Li, Ernsting, Wishart et al.: "A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast." in: The Journal of biological chemistry, Vol. 272, Issue 47, pp. 29403-6, 1997 (PubMed).

Bembenek, Yu: "Regulation of the anaphase-promoting complex by the dual specificity phosphatase human Cdc14a." in: The Journal of biological chemistry, Vol. 276, Issue 51, pp. 48237-42, 2001 (PubMed).

Mailand, Lukas, Kaiser et al.: "Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation." in: Nature cell biology, Vol. 4, Issue 4, pp. 317-22, 2002 (PubMed).

Kaiser, Zimmerman, Charbonneau et al.: "Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase." in: Molecular biology of the cell, Vol. 13, Issue 7, pp. 2289-300, 2002 (PubMed).

Validation Images
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