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BIM antibody (BCL2-Like 11 (Apoptosis Facilitator)) (AA 134-160)

Details for Product anti-BCL2L11 Antibody No. ABIN652493, Supplier: Login to see
Antigen
  • bim
  • BAM
  • BIM
  • BOD
  • 1500006F24Rik
  • Bim
  • Bod
  • BimL
  • BIMEL
Alternatives
anti-Human BIM antibody for ELISA
Epitope
AA 134-160, Center
78
23
14
14
13
13
13
12
11
8
7
7
6
5
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
285
140
110
4
2
2
2
2
2
Host
Rabbit
255
16
16
14
7
Clonality (Clone)
Polyclonal ()
Conjugate
This BIM antibody is un-conjugated
16
14
9
8
8
8
4
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
230
135
101
53
37
33
32
26
16
8
3
2
2
2
2
Supplier
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Immunogen This BCL2L11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-160 AA from the Central region of human BCL2L11.
Clone RB22105
Isotype Ig
Specificity This BCL2L11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140~169 amino acids from the Center region of human BCL2L11.
Predicted Reactivity Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name BCL2L11 (BCL2L11 Antibody Abstract)
Background BCL2L11 belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator.
Synonyms: Bcl-2-like protein 11, Bcl2-L-11, Bcl2-interacting mediator of cell death, BIM, BCL2L11
Molecular Weight 22171 DA
Gene ID 10018
UniProt O43521
Research Area Apoptosis/Necrosis, Neurology
Pathways PI3K-Akt Signaling, Neurotrophin Signaling Pathway
Application Notes WB = 1:1000, IHC (p) = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.39 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-BIM antibody (BCL2-Like 11 (Apoptosis Facilitator)) (AA 134-160) (ABIN652493) Western blot analysis of BCL2L11 Antibody (Center) (ABIN652493) in K562, HL-60 cell l...
Immunohistochemistry (IHC) image for anti-BIM antibody (BCL2-Like 11 (Apoptosis Facilitator)) (AA 134-160) (ABIN652493) Formalin-fixed and paraffin-embedded human colon carcinoma reacted with BCL2L11 Antib...
Flow Cytometry (FACS) image for anti-BIM antibody (BCL2-Like 11 (Apoptosis Facilitator)) (AA 134-160) (ABIN652493) Flow cytometric analysis of WiDr cells using BCL2L11 Antibody (Center)(bottom histogr...
Background publications Hippe, Weber, Zhou et al.: "Toxoplasma gondii infection confers resistance against BimS-induced apoptosis by preventing the activation and mitochondrial targeting of pro-apoptotic Bax." in: Journal of cell science, Vol. 122, Issue Pt 19, pp. 3511-21, 2009 (PubMed).

Putcha, Le, Frank et al.: "JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis." in: Neuron, Vol. 38, Issue 6, pp. 899-914, 2003 (PubMed).