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NOD1 antibody (Nucleotide-Binding Oligomerization Domain Containing 1) (AA 923-951)

Details for Product anti-NOD1 Antibody No. ABIN652666, Supplier: Log in to see
Antigen
  • CARD4
  • CLR7.1
  • NLRC1
  • C230079P11
  • Card4
  • F830007N14Rik
  • Nlrc1
  • RGD1562269
Epitope
AA 923-951, C-Term
35
10
9
8
7
6
5
5
4
3
3
3
3
2
2
2
2
2
2
1
1
Reactivity
Human
106
43
24
2
2
2
1
Host
Rabbit
105
13
6
Clonality (Clone)
Polyclonal ()
Conjugate
This NOD1 antibody is un-conjugated
6
6
5
5
5
5
1
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
112
65
21
21
12
5
5
5
2
2
2
1
Supplier
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Immunogen This CARD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 923-951 AA from the C-terminal region of human CARD4.
Clone RB21998
Isotype Ig
Specificity This CARD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 924~953 amino acids from the C-terminal region of human CARD4.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CARD4 (NOD1 Antibody Abstract)
Background CARD4 is a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid.
Synonyms: Nucleotide-binding oligomerization domain-containing protein 1, Caspase recruitment domain-containing protein 4, CARD4, NOD1
Molecular Weight 107691 DA
Gene ID 10392
UniProt Q9Y239
Research Area Apoptosis/Necrosis
Application Notes WB = 1:1000, IHC (p) = 1:50-100, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.41 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-NOD1 antibody (Nucleotide-Binding Oligomerization Domain Containing 1) (AA 923-951) (ABIN652666) Western blot analysis of CARD4 Antibody (C-term) (ABIN652666) in HL-60 cell line lysa...
Immunohistochemistry (IHC) image for anti-NOD1 antibody (Nucleotide-Binding Oligomerization Domain Containing 1) (AA 923-951) (ABIN652666) Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with CARD4 ...
Flow Cytometry (FACS) image for anti-NOD1 antibody (Nucleotide-Binding Oligomerization Domain Containing 1) (AA 923-951) (ABIN652666) CARD4 Antibody (C-term) (ABIN652666) flow cytometric analysis of HL-60 cells (bottom ...
Background publications Inohara, Koseki, Lin et al.: "An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways." in: The Journal of biological chemistry, Vol. 275, Issue 36, pp. 27823-31, 2000 (PubMed).

Inohara, Koseki, del Peso et al.: "Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB." in: The Journal of biological chemistry, Vol. 274, Issue 21, pp. 14560-7, 1999 (PubMed).