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alpha 1b Adrenergic Receptor antibody (Adrenergic, alpha-1B-, Receptor) (AA 270-297)

Details for Product anti-ADRA1B Antibody No. ABIN653353, Supplier: Log in to see
Antigen
  • ADRA1
  • ALPHA1BAR
  • LOC100136712
  • RDC5
  • [a]1b
Alternatives
anti-Human alpha 1b Adrenergic Receptor antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
AA 270-297, Center
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25
17
16
10
10
5
5
3
2
2
2
1
1
1
1
Reactivity
Human
121
38
35
4
4
4
2
1
1
1
1
Host
Rabbit
107
13
1
Clonality (Clone)
Polyclonal ()
Conjugate
This alpha 1b Adrenergic Receptor antibody is un-conjugated
6
6
6
5
5
5
2
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
76
61
29
20
12
9
3
3
2
Supplier
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Immunogen This ADRA1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-297 AA from the Central region of human ADRA1B.
Clone RB25170
Isotype Ig
Specificity This ADRA1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 276~306 amino acids from the Central region of human ADRA1B.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus),Rabbit
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ADRA1B (ADRA1B Antibody Abstract)
Background Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This protein encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This protein comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.
Synonyms: Alpha-1B adrenergic receptor, Alpha-1B adrenoreceptor, ADRA1B
Molecular Weight 56,836 DA
Gene ID 147
UniProt P35368
Research Area Cell Structure
Pathways AMPK Signaling
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-alpha 1b Adrenergic Receptor antibody (Adrenergic, alpha-1B-, Receptor) (AA 270-297) (ABIN653353) Western blot analysis of ADRA1B Antibody (Center) (ABIN653353) in NCI-H460 cell line ...
Immunohistochemistry (IHC) image for anti-alpha 1b Adrenergic Receptor antibody (Adrenergic, alpha-1B-, Receptor) (AA 270-297) (ABIN653353) Formalin-fixed and paraffin-embedded human brain with ADRA1B Antibody (Center), which...
Background publications Mathias, Grant, Rafaels, Hand, Gao, Vergara, Tsai, Yang, Campbell, Foster, Gao, Togias, Hansel, Diette, Adkinson, Liu, Faruque, Dunston, Watson, Bracken, Hoh, Maul, Maul, Jedlicka, Murray, Hetmanski, Ashworth, Ongaco, Hetrick, Doheny, Pugh, Rotimi, Ford, : "A genome-wide association study on African-ancestry populations for asthma." in: The Journal of allergy and clinical immunology, Vol. 125, Issue 2, pp. 336-346.e4, 2010 (PubMed).