Leucyl/cystinyl Aminopeptidase (LNPEP) (N-Term) antibody

Antigen: Leucyl/cystinyl Aminopeptidase (LNPEP)

Synonyms: fb73h12, wu:fb73h12

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN654230

Additional Information

Alternative name: LNPEP

Gene ID: 4012

UniProt: NP_005566.2, NP_787116.2, Q9UIQ6

Immunogen: This LNPEP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of human LNPEP.

Isotype: Ig

Description: Other names: Leucyl-cystinyl aminopeptidase,LNPEP,OTASE

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This LNPEP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of human LNPEP.

Molecular Weight: 117349 DA

Comments:

Background: This gene encodes a zinc-dependent aminopeptidase that cleaves vasopressin, oxytocin, lys-bradykinin, met-enkephalin, dynorphin A and other peptide hormones. The protein can be secreted in maternal serum, reside in intracellular vesicles with the insulin-responsive glucose transporter GLUT4, or form a type II integral membrane glycoprotein. The protein catalyzes the final step in the conversion of angiotensinogen to angiotensin IV (AT4) and is also a receptor for AT4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500 Immunohistochemistry ~~ 1:50~100

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Metabolism

Restrictions: For Research Use only

Publications

Product: Saveanu, Carroll, Weimershaus et al.: "IRAP identifies an endosomal compartment required for MHC class I cross-presentation." in: Science (New York, N.Y.), Vol. 325, Issue 5937, pp. 213-7, 2009 (PubMed).

Georgiadou, Hearn, Evnouchidou et al.: "Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 3, pp. 1584-92, 2010 (PubMed).