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DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 11 (DDX11) (AA 656-683), (Center) antibody

Details for Product No. ABIN654411, Supplier: Log in to see
Antigen
  • 4732462I11Rik
  • CHL1
  • CHLR1
  • essa15a
  • KRG2
  • WABS
Epitope
AA 656-683, Center
18
16
16
8
7
5
3
2
1
1
1
1
Reactivity
Human, Mouse (Murine)
67
5
2
Host
Rabbit
58
9
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
5
5
5
4
4
4
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Western Blotting (WB)
50
35
31
11
8
6
6
2
1
1
Supplier
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Immunogen This DDX11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 656-683 AA from the Central region of human DDX11.
Clone RB27628
Isotype Ig
Specificity This DDX11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 663-691 amino acids from the Central region of human DDX11.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name DDX11 (DDX11 Antibody Abstract)
Background DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. DDX11 encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. DDX11 is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability.
Synonyms: DDX11,Probable ATP-dependent RNA helicase DDX11,CHL1, CHLR1, KRG2
Molecular Weight 108313 DA
Gene ID 1663
NCBI Accession NP_004390, NP_689651
UniProt Q96FC9
Research Area Transcription Factors, Signaling, Chromatin, Metabolism, Cell Structure
Application Notes WB = 1:1000, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 11 (DDX11) (AA 656-683), (Center) antibody (ABIN654411) DDX11 Antibody (Center) (ABIN654411) western blot analysis in mouse Neuro-2a cell lin...
Background publications Leman, Noguchi, Lee, Noguchi: "Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesion." in: Journal of cell science, Vol. 123, Issue Pt 5, pp. 660-70, 2010 (PubMed).

Farina, Shin, Kim, Bermudez, Kelman, Seo, Hurwitz: "Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1." in: The Journal of biological chemistry, Vol. 283, Issue 30, pp. 20925-36, 2008 (PubMed).

Parish, Bean, Park, Androphy: "ChlR1 is required for loading papillomavirus E2 onto mitotic chromosomes and viral genome maintenance." in: Molecular cell, Vol. 24, Issue 6, pp. 867-76, 2006 (PubMed).

Parish, Rosa, Wang, Lahti, Doxsey, Androphy: "The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells." in: Journal of cell science, Vol. 119, Issue Pt 23, pp. 4857-65, 2006 (PubMed).