Inhibitor of DNA Binding 1, Dominant Negative Helix-Loop-Helix Protein (ID1) (AA 66-93), (Center) antibody

Details for Product No. ABIN655663
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Antigen
Synonyms ID1, id6, cb108, wu:fb57e11, AI323524, D2Wsu140e, Idb1, bHLHb24, ID125A, ID
Epitope
AA 66-93, Center
(11), (8), (8), (3), (2), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(63), (29), (26), (24), (24), (12), (12)
Host
Rabbit
(37), (26), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)
(43), (29), (20), (16), (9), (8), (8), (7), (2), (1), (1)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN655663
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Immunogen This ID1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-93 AA from the Central region of human ID1.
Clone RB29169
Isotype Ig
Specificity This ID1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 73-101 amino acids from the Central region of human ID1.
Predicted Reactivity Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ID1
Background The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Synonyms: RB29238
Molecular Weight 16133 DA
Gene ID 3397
NCBI Accession NP_851998, NP_002156
UniProt P41134
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50, IF = 1:10-50, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.35 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Inhibitor of DNA Binding 1, Dominant Negative Helix-Loop-Helix Protein (ID1) (AA 66-93), (Center) antibody Confocal immunofluorescent analysis of ID1 Antibody (Center)(ABIN655663) with U-251MG cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).
Background publications Qian, Lee, Park et al.: "Id1 enhances RING1b E3 ubiquitin ligase activity through the Mel-18/Bmi-1 polycomb group complex." in: Oncogene, Vol. 29, Issue 43, pp. 5818-27, 2010 (PubMed).

Hamajima, Komori, Preciado et al.: "The role of inhibitor of DNA-binding (Id1) in hyperproliferation of keratinocytes: the pathological basis for middle ear cholesteatoma from chronic otitis media." in: Cell proliferation, Vol. 43, Issue 5, pp. 457-63, 2010 (PubMed).

Validation Images
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