Aldo-keto Reductase Family 1, Member C2 (AKR1C2) (C-Term), (AA 296-323) antibody

Details for Product No. ABIN656180
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Antigen
Epitope
C-Term, AA 296-323
(8), (8), (6), (4), (3), (3), (3), (1), (1), (1)
Reactivity
Human
(58), (13), (12), (12), (1), (1)
Host
Rabbit
(49), (8)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(47), (26), (10), (9), (5), (4), (2), (2), (1), (1)
Pubmed 1 reference available
Quantity 400 μL
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Catalog No. ABIN656180
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Immunogen This AKR1C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-323 AA from the C-terminal region of human AKR1C2.
Clone RB32249
Isotype Ig
Specificity This AKR1C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 295-323 amino acids from the C-terminal region of human AKR1C2.
Predicted Reactivity Monkey
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name AKR1C2
Background This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
Synonyms: AKR1C2,Aldo-keto reductase family 1 member C2,DDH2
Molecular Weight 36735 DA
Gene ID 1646
NCBI Accession NP_995317
UniProt P52895
Research Area Signaling, Protein Modifications, Metabolism, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.45 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment AKR1C2 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Aldo-keto Reductase Family 1, Member C2 (AKR1C2) (C-Term), (AA 296-323) antibody AKR1C2 Antibody (C-term) (ABIN656180) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Background publications Wang, Chorley, Pittman et al.: "Genetic variation and antioxidant response gene expression in the bronchial airway epithelium of smokers at risk for lung cancer." in: PLoS ONE, Vol. 5, Issue 8, pp. e11934, 2010 (PubMed).

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