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Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) (Center) antibody
Alternatives Western Blotting (WB), ELISA
|2 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This EIF4EBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-69 amino acids from the Central region of human EIF4EBP1.|
|Description||Other names: Eukaryotic translation initiation factor 4E-binding protein 1,EIF4EBP1,|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This EIF4EBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-69 amino acids from the Central region of human EIF4EBP1.|
|Molecular Weight||12580 DA|
Background: This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq].
|Synonyms||BP-1, 4EBP1, 4E-BP1, PHAS-I, MGC4316, 4e-bp1, AA959816, 153432_at, 43-BP, 4E-BP, 4EBP, BcDNA.HL08053, BcDNA:HL08053, CT8705, Dm 4E-BP, Phas1, anon-WO0172774.158, d4E-BP, d4E-BP1, d4EBP, eIF4E-BP, l(2)k07736, l(2)k13517, pp20, thor, DmelCG8846, CG8846, EIF4EBP1, fc04h09, Eif4ebp1, MGC64137, wu:fc04h09|
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||EIF4EBP1 Antibody (Center) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.|
|Research Area||Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure|
|Restrictions||For Research Use only|
Aoyagi, Gaspar, Shenk: "Human cytomegalovirus UL69 protein facilitates translation by associating with the mRNA cap-binding complex and excluding 4EBP1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 6, pp. 2640-5, 2010 (PubMed).
She, Halilovic, Ye et al.: "4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors." in: Cancer cell, Vol. 18, Issue 1, pp. 39-51, 2010 (PubMed).