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CCR4-NOT Transcription Complex, Subunit 8 (CNOT8) (AA 33-60), (N-Term) antibody

Details for Product No. ABIN656816, Supplier: Login to see
Antigen
  • calif
  • pop2
  • zgc:63844
  • wu:fe49a05
  • caf1
  • hcaf1
  • CAF1
  • CALIF
  • Caf1b
  • POP2
  • hCAF1
  • 1500015I04Rik
  • 1810022F04Rik
  • AA536816
  • AU015770
  • AU043059
Epitope
AA 33-60, N-Term
29
22
16
7
3
2
2
2
1
1
1
Reactivity
Human
80
23
19
Host
Rabbit
76
6
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
6
6
6
5
5
5
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
64
45
19
14
11
7
5
5
3
2
Supplier
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Immunogen This CNOT8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-60 AA from the N-terminal region of human CNOT8.
Clone RB19574
Isotype Ig
Specificity This CNOT8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-60 amino acids from the N-terminal region of human CNOT8.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CNOT8 (CNOT8 Antibody Abstract)
Background Ubiquitous transcription factor required for a diverse set of processes. The CCR4-NOT complex functions as general transcription regulation complex.
Synonyms: CCR4-NOT transcription complex subunit 8,CNOT8,CALIF, POP2
Molecular Weight 33540 DA
Gene ID 9337
NCBI Accession NP_004770
UniProt Q9UFF9
Research Area Translation Factors, Transcription Factors, Signaling, Cell Structure
Pathways
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment CNOT8 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-CCR4-NOT Transcription Complex, Subunit 8 (CNOT8) (AA 33-60), (N-Term) antibody (ABIN656816) Western blot analysis of CNOT8 (arrow) using rabbit polyclonal CNOT8 Antibody (N-term...
Background publications Ruan, Osawa, Hosoda et al.: "Quantitative characterization of Tob interactions provides the thermodynamic basis for translation termination-coupled deadenylase regulation." in: The Journal of biological chemistry, Vol. 285, Issue 36, pp. 27624-31, 2010 (PubMed).

Marchese, Aubareda, Tudor et al.: "MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment." in: The Journal of biological chemistry, Vol. 285, Issue 36, pp. 27590-600, 2010 (PubMed).

Piao, Zhang, Wu et al.: "CCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cells." in: Molecular and cellular biology, Vol. 30, Issue 6, pp. 1486-94, 2010 (PubMed).

Aslam, Mittal, Koch et al.: "The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation." in: Molecular biology of the cell, Vol. 20, Issue 17, pp. 3840-50, 2009 (PubMed).

Lau, Kolkman, van Schaik et al.: "Human Ccr4-Not complexes contain variable deadenylase subunits." in: The Biochemical journal, Vol. 422, Issue 3, pp. 443-53, 2009 (PubMed).