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AFG3L2 antibody (AFG3 ATPase Family Gene 3-Like 2 (S. Cerevisiae)) (AA 52-80)

Details for Product anti-AFG3L2 Antibody No. ABIN657143, Supplier: Log in to see
Antigen
  • 2310036I02Rik
  • AW260507
  • Emv66
  • MGC147390
  • par
  • SCA28
  • si:ch211-12e1.4
  • SPAX5
Epitope
AA 52-80, N-Term
16
15
3
2
2
1
1
1
1
Reactivity
Human
64
11
11
1
1
1
1
1
Host
Rabbit
56
8
Clonality (Clone)
Polyclonal ()
Conjugate
This AFG3L2 antibody is un-conjugated
7
7
6
2
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
56
38
30
7
6
3
1
1
Supplier
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Immunogen This AFG3L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-80 AA from the N-terminal region of human AFG3L2.
Clone RB33011
Isotype Ig
Specificity This AFG3L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-80 amino acids from the N-terminal region of human AFG3L2.
Predicted Reactivity Cow (Bovine),Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name AFG3L2 (AFG3L2 Antibody Abstract)
Background This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders.
Synonyms: AFG3-like protein 2,AFG3L2,
Research Area Signaling, Protein Modifications, Cell Structure, Chromatin, Neurology, Metabolism
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Western Blotting (WB) image for anti-AFG3L2 antibody (AFG3 ATPase Family Gene 3-Like 2 (S. Cerevisiae)) (AA 52-80) (ABIN657143) AFG3L2 Antibody (N-term) western blot analysis in MDA-MB453,MCF-7,Jurkat cell line l...
Immunohistochemistry (IHC) image for anti-AFG3L2 antibody (AFG3 ATPase Family Gene 3-Like 2 (S. Cerevisiae)) (AA 52-80) (ABIN657143) AFG3L2 Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin...
Background publications Edener, Wöllner, Hehr, Kohl, Schilling, Kreuz, Bauer, Bernard, Gillessen-Kaesbach, Zühlke: "Early onset and slow progression of SCA28, a rare dominant ataxia in a large four-generation family with a novel AFG3L2 mutation." in: European journal of human genetics : EJHG, Vol. 18, Issue 8, pp. 965-8, 2010 (PubMed).

Di Bella, Lazzaro, Brusco, Plumari, Battaglia, Pastore, Finardi, Cagnoli, Tempia, Frontali, Veneziano, Sacco, Boda, Brussino, Bonn, Castellotti, Baratta, Mariotti, Gellera, Fracasso, Magri, Langer, Plevani, Di Donato, Muzi-Falconi, Taroni: "Mutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28." in: Nature genetics, Vol. 42, Issue 4, pp. 313-21, 2010 (PubMed).

Augustin, Gerdes, Lee, Tsai, Langer, Tatsuta: "An intersubunit signaling network coordinates ATP hydrolysis by m-AAA proteases." in: Molecular cell, Vol. 35, Issue 5, pp. 574-85, 2009 (PubMed).