FCGR3A antibody (Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a)) (AA 226-254)

Details for Product anti-FCGR3A Antibody No. ABIN657457, Supplier: Log in to see
Antigen
  • CD16
  • CD16A
  • FCG3
  • FCGR3
  • FCGRIII
  • FCR-10
  • FCRIII
  • FCRIIIA
  • IGFR3
  • Fcgr4
  • Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
  • Fc fragment of IgG, low affinity IIIa, receptor
  • FCGR3A
  • Fcgr3a
Epitope
AA 226-254, C-Term
21
16
12
10
6
5
5
4
4
4
3
3
2
1
1
1
Reactivity
Human
301
59
13
12
9
1
1
1
1
1
1
Host
Rabbit
261
54
Clonality (Clone)
Polyclonal ()
Conjugate
This FCGR3A antibody is un-conjugated
20
18
17
13
13
12
11
10
10
10
10
10
10
10
10
9
9
9
3
2
2
1
1
1
Application
Western Blotting (WB)
225
80
62
52
37
28
28
22
12
8
3
3
1
Options
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Immunogen This FCGR3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-254 AA from the C-terminal region of human FCGR3A.
Clone RB33601
Isotype Ig
Specificity This FCGR3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 225-254 amino acids from the C-terminal region of human FCGR3A.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name FCGR3A (FCGR3A Antibody Abstract)
Background This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms: Low affinity immunoglobulin gamma Fc region receptor III-A,FCGR3A,CD16A, FCG3, FCGR3, IGFR3
Molecular Weight 29089 DA
Gene ID 2214
NCBI Accession NP_001121064, NP_001121065, NP_000560, NP_001121068, NP_001121067
UniProt P08637
Research Area Cell Signaling, Cell Structure, Protein Modifications
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment FCGR3A Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-FCGR3A antibody (Fc Fragment of IgG, Low Affinity IIIa, Receptor (CD16a)) (AA 226-254) (ABIN657457) FCGR3A Antibody (C-term) (ABIN657457) western blot analysis in NCI-H460 cell line lys...
Background publications Dornan, Spleiss, Yeh, Duchateau-Nguyen, Dufour, Zhi, Robak, Moiseev, Dmoszynska, Solal-Celigny, Warzocha, Loscertales, Catalano, Afanasiev, Larratt, Rossiev, Bence-Bruckler, Geisler, Montillo, Wenger, Weisser: "Effect of FCGR2A and FCGR3A variants on CLL outcome." in: Blood, Vol. 116, Issue 20, pp. 4212-22, 2010 (PubMed).

Li, Chen, Evens, Lee, Liao, Yu, Tung, Su: "Rituximab-induced late-onset neutropenia in newly diagnosed B-cell lymphoma correlates with Fc receptor FcγRIIIa 158(V/F) polymorphism." in: American journal of hematology, Vol. 85, Issue 10, pp. 810-2, 2010 (PubMed).