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MCL-1 antibody (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1) (AA 217-245)

Details for Product anti-MCL1 Antibody No. ABIN657627, Supplier: Log in to see
Antigen
  • AW556805
  • bcl2-L-3
  • BCL2L3
  • EAT
  • mcl-1
  • Mcl-1
  • MCL1-ES
  • mcl1/EAT
  • MCL1L
  • MCL1S
  • TM
Alternatives
anti-Human MCL-1 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
AA 217-245, Center
34
23
22
15
15
14
14
14
11
10
9
5
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
327
109
75
10
9
5
5
3
3
2
1
1
1
Host
Rabbit
223
93
20
2
Clonality (Clone)
Polyclonal ()
Conjugate
This MCL-1 antibody is un-conjugated
12
10
10
6
5
5
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
280
144
116
85
83
53
33
27
27
24
7
6
1
Supplier
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Immunogen This MCL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-245 AA from the Central region of human MCL1.
Clone RB33638
Isotype Ig
Specificity This MCL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-245 amino acids from the Central region of human MCL1.
Predicted Reactivity Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name MCL1 (MCL1 Antibody Abstract)
Background This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.
Synonyms: Induced myeloid leukemia cell differentiation protein Mcl-1,MCL1,BCL2L3
Molecular Weight 37337 DA
Gene ID 4170
NCBI Accession NP_068779, NP_877495
UniProt Q07820
Research Area Ubiquitin-related antibodies, Apoptosis/Necrosis, Phospho-specific antibodies, Cell Structure, Protein Modifications, Cell Cycle
Pathways MAPK Signaling
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.49 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment MCL1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-MCL-1 antibody (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1) (AA 217-245) (ABIN657627) MCL1 Antibody (Center) (ABIN657627) western blot analysis in Y79 cell line lysates (3...
Background publications Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, 2010 (PubMed).

Maurer, Charvet, Wagman, Dejardin, Green: "Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1." in: Molecular cell, Vol. 21, Issue 6, pp. 749-60, 2006 (PubMed).

Domina, Vrana, Gregory, Hann, Craig: "MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol." in: Oncogene, Vol. 23, Issue 31, pp. 5301-15, 2004 (PubMed).