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B-Cell CLL/lymphoma 2 (BCL2) (Center) antibody

Antigen

B-Cell CLL/lymphoma 2 (BCL2)
Synonyms Bcl-2, bcl-2, BCL2
Binding Site
Alternatives

Center
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), ELISA
1 reference available
Certificates ISO 9001:2008
Catalog no. ABIN657744
Quantity 0.1 mg  (0.25 mg/ml)
Price 280.50 $   Plus shipping costs $45.00
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anti-B-Cell CLL/lymphoma 2 (BCL2) (Center) antibody

Additional Information
Application Details Publications Images Alternatives back to top

Alternative name BCL2
Gene ID 596
UniProt P10415, NP_000624.2
Immunogen This BCL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-114 amino acids from the Central region of human BCL2.
Isotype Ig
Description Other names: Apoptosis regulator Bcl-2,BCL2,
Characteristics Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Specificity This BCL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-114 amino acids from the Central region of human BCL2.
Molecular Weight 26266 DA
Comments

Background: This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq].

Application Details
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Application Notes The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500
Concentration 0.25 mg/ml
Purification Purified
Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage BCL2 Antibody (Center) can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Structure, Protein Modifications, Cancer, Chromatin, Signaling
Restrictions For Research Use only

Publications
Application Details Images Alternatives back to top

Product Feng, Stachura, White et al.: "T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation." in: Cancer cell, Vol. 18, Issue 4, pp. 353-66, 2010 (PubMed).

Alternatives
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Alternatives for antigen "B-Cell CLL/lymphoma 2 (BCL2)", type "Antibodies"
Hosts Rabbit (173), Mouse (82), Goat (7), Sheep (3), Pig (1)
Reactivities Human (232), Mouse (Murine) (97), Rat (Rattus) (83), Dog (Canine) (54), Cow (Bovine) (44), Pig (Porcine) (42), Horse (Equine) (41), Chicken (19), Guinea Pig (18), Sheep (Ovine) (5), Cat (Feline) (3), Rabbit (3), Gerbil (1)
Applications Western Blotting (WB) (171), Immunofluorescence (IF) (89), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (87), ELISA (85), Immunoprecipitation (IP) (58), Immunohistochemistry (IHC) (55), Flow Cytometry (FACS) (37), Immunocytochemistry (ICC) (25), Immunohistochemistry (Frozen Sections) (IHC (fro)) (24), Immunohistochemistry (Fixed) (IHC (fx)) (10), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (10), Dot Blot (Dot) (6), Immunoelectron Microscopy (IEM) (2), Cellular Assay (CA) (1), Immunoassay (IA) (1), Immunostaining (ISt) (1)
Conjugates Biotin (10), FITC (9), PE (7), Alexa Fluor 350 (5), Alexa Fluor 488 (5), Alexa Fluor 555 (5), Alexa Fluor 647 (5), PE,Cy5.5 (5), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), Gold (2), HRP (2), PE,Cy3 (2), PE,Cy5 (2), PE,Cy7 (2), RPE (1)
Epitopes AA 41-54 (13), N-Term (12), pSer70 (11), pThr56 (10), pSer70,Internal Region (6), pThr129 (5), Internal Region (4), AA 51-54 (2), AA 61-76 (2), AA 67-86 (2), BH3 Domain (2), C-Term (2), AA 1-195 (1), AA 21-34 (1), Middle Region (1), Ser70 (1), Thr56 (1), pSer592 (1), pSer87 (1), pSer99 (1), pThr69 (1)