Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (N-Term), (AA 17-45) antibody

Details for Product No. ABIN657756
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Antigen
Synonyms xCaspase-6, mch2, caspase-6, zgc:112960, CASP6, casp6, Mch2, mCASP-6, MCH2
Epitope
N-Term, AA 17-45
(48), (33), (23), (12), (12), (7), (7), (6), (4), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(196), (92), (77), (13), (6), (2), (1)
Host
Rabbit
(180), (29), (4)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(11), (10), (8), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(171), (96), (63), (49), (40), (30), (22), (13), (8), (1), (1), (1), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN657756
291.50 $
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Immunogen This CASP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-45 AA from the N-terminal region of human CASP6.
Clone RB33636
Isotype Ig
Specificity This CASP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-45 amino acids from the N-terminal region of human CASP6.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CASP6
Background This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq].
Synonyms: Caspase-6,CASP6,MCH2
Molecular Weight 33310 DA
Gene ID 839
NCBI Accession NP_001217, NP_116787
UniProt P55212
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Protein Modifications, Metabolism, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.41 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment CASP6 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (N-Term), (AA 17-45) antibody Western blot analysis of CASP6 (arrow) using rabbit polyclonal CASP6 Antibody (N-term) (ABIN657756). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CASP6 gene.
Background publications Halawani, Tessier, Anzellotti et al.: "Identification of Caspase-6-mediated processing of the valosin containing protein (p97) in Alzheimer's disease: a novel link to dysfunction in ubiquitin proteasome system-mediated protein degradation." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 17, pp. 6132-42, 2010 (PubMed).

Lee, Choi, Choi et al.: "Polymorphisms in the caspase genes and the risk of lung cancer." in: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Vol. 5, Issue 8, pp. 1152-8, 2010 (PubMed).

Würstle, Laussmann, Rehm: "The caspase-8 dimerization/dissociation balance is a highly potent regulator of caspase-8, -3, -6 signaling." in: The Journal of biological chemistry, Vol. 285, Issue 43, pp. 33209-18, 2010 (PubMed).

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