EPH Receptor A2 antibody (EPHA2) (AA 920-970)

Details for Product anti-EPHA2 Antibody No. ABIN669201, Supplier: Log in to see
Antigen
  • EPHA2
  • epha2
  • MGC89505
  • ARCC2
  • CTPA
  • CTPP1
  • CTRCT6
  • ECK
  • AW545284
  • Eck
  • Myk2
  • Sek-2
  • Sek2
  • EPH receptor A2
  • EphA2
  • epoxide hydrolase
  • Eph receptor A2
  • EPHA2
  • epha2
  • ephA2
  • Epha2
Alternatives
anti-Human EPH Receptor A2 antibody for Flow Cytometry
Epitope
AA 920-970
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Reactivity
Human, Mouse (Murine), Rat (Rattus)
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Host
Rabbit
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Clonality
Polyclonal
Conjugate
This EPH Receptor A2 antibody is un-conjugated
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Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Options
Supplier
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Supplier Product No.
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Immunogen KLH conjugated synthetic peptide derived from human EphA2
Isotype IgG
Purification Purified by Protein A.
Alternative Name EphA2 (EPHA2 Antibody Abstract)
Background

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

Subcellular location: Cytoplasm

Synonyms: ECK, CTPA, ARCC2, CTPP1, CTRCT6, Ephrin type-A receptor 2, Epithelial cell kinase, Tyrosine-protein kinase receptor ECK, EPHA2

Gene ID 1969
UniProt P29317
Research Area Signaling
Pathways RTK Signaling
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months
Supplier Images
Immunohistochemistry (IHC) image for anti-EPH Receptor A2 (EPHA2) (AA 920-970) antibody (ABIN669201) Formalin-fixed and paraffin embedded mouse intestine labeled with Rabbit Anti EphA2/E...
Immunohistochemistry (IHC) image for anti-EPH Receptor A2 (EPHA2) (AA 920-970) antibody (ABIN669201) Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti EphA2/Eph rec...
Immunofluorescence (IF) image for anti-EPH Receptor A2 (EPHA2) (AA 920-970) antibody (ABIN669201) Formalin-fixed and paraffin-embedded rat brain labeled with Anti-EphA2/Eph receptor A...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-EPH Receptor A2 (EPHA2) (AA 920-970) antibody (ABIN669201) Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-EphA2 Polyclo...
Product cited in: Wu, Fu, Zhou, Gong, Liu, Qiao, Li: "HIF-1? and HIF-2?: siblings in promoting angiogenesis of residual hepatocellular carcinoma after high-intensity focused ultrasound ablation." in: PLoS ONE, Vol. 9, Issue 2, pp. e88913, 2014 (PubMed).

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