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HMGB1 antibody (AA 75-170)

HMGB1 Reactivity: Human, Mouse, Rat WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN671616
  • Target See all HMGB1 Antibodies
    HMGB1 (High Mobility Group Box 1 (HMGB1))
    Binding Specificity
    • 21
    • 16
    • 15
    • 11
    • 10
    • 8
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 75-170
    Reactivity
    • 156
    • 87
    • 86
    • 14
    • 12
    • 12
    • 10
    • 8
    • 7
    • 7
    • 7
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 136
    • 30
    • 2
    • 2
    • 1
    • 1
    Rabbit
    Clonality
    • 126
    • 46
    Polyclonal
    Conjugate
    • 89
    • 17
    • 17
    • 7
    • 7
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This HMGB1 antibody is un-conjugated
    Application
    • 145
    • 63
    • 47
    • 45
    • 32
    • 31
    • 26
    • 25
    • 21
    • 10
    • 8
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Human, Mouse, Rat
    Predicted Reactivity
    Cow
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human HMGB1
    Isotype
    IgG
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Li, Xu, Xu, Cai, Sun, Yang, Sun, Lu: "Methotrexate affects HMGB1 expression in rheumatoid arthritis, and the downregulation of HMGB1 prevents rheumatoid arthritis progression." in: Molecular and cellular biochemistry, Vol. 420, Issue 1-2, pp. 161-70, (2016) (PubMed).

    Li, Jia, Ji, Gong, Wang, Zhang, Wang, Zang: "The neutrophil elastase inhibitor, sivelestat, attenuates sepsis-related kidney injury in rats." in: International journal of molecular medicine, Vol. 38, Issue 3, pp. 767-75, (2016) (PubMed).

    Sun, Zhang, Cui, Chen, Xie, Zhou, Liu, Peng, Zhang: "High mobility group box-1 and its clinical value in breast cancer." in: OncoTargets and therapy, Vol. 8, pp. 413-9, (2015) (PubMed).

    Zhang, He, Wang, Zhou, Ma: "Omega-3 polyunsaturated fatty acids inhibit the increase in cytokines and chemotactic factors induced in vitro by lymph fluid from an intestinal ischemia-reperfusion injury model." in: Nutrition (Burbank, Los Angeles County, Calif.), Vol. 31, Issue 3, pp. 508-14, (2015) (PubMed).

    Luan, Kan, Xu, Lv, Jiang: "Rosmarinic acid protects against experimental diabetes with cerebral ischemia: relation to inflammation response." in: Journal of neuroinflammation, Vol. 10, pp. 28, (2013) (PubMed).

    Zhao, Hu, Sun, Sun: "The high mobility group box 1 protein of Sciaenops ocellatus is a secreted cytokine that stimulates macrophage activation." in: Developmental and comparative immunology, Vol. 35, Issue 10, pp. 1052-8, (2011) (PubMed).

    Jiang, Fu, Tian, Zhu, Hou: "Curculigoside A attenuates experimental cerebral ischemia injury in vitro and vivo." in: Neuroscience, Vol. 192, pp. 572-9, (2011) (PubMed).

  • Target
    HMGB1 (High Mobility Group Box 1 (HMGB1))
    Alternative Name
    HMGB1 (HMGB1 Products)
    Synonyms
    HMG1 antibody, HMG3 antibody, SBP-1 antibody, DEF antibody, HMG-1 antibody, Hmg1 antibody, amphoterin antibody, p30 antibody, hmgb1 antibody, ik:tdsubc_1a5 antibody, wu:fb23c02 antibody, xx:tdsubc_1a5 antibody, zgc:56110 antibody, zgc:77104 antibody, hmg-1 antibody, hmg3 antibody, sbp-1 antibody, hmg1 antibody, HMGB1 antibody, Ac2-008 antibody, high mobility group box 1 antibody, high-mobility group box 1 antibody, high mobility group box 1a antibody, high mobility group box 1 L homeolog antibody, high mobility group protein B1 antibody, HMGB1 antibody, Hmgb1 antibody, hmgb1 antibody, hmgb1a antibody, hmgb1.L antibody, LOC100359149 antibody
    Background

    Synonyms: HMG1, HMG3, SBP-1, High mobility group protein B1, High mobility group protein 1, HMG-1, HMGB1

    Background: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity).

    Gene ID
    3146
    UniProt
    P09429
    Pathways
    p53 Signaling, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, Inflammasome
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