Jagged 2 (JAG2) antibody

Antigen: Jagged 2 (JAG2)

Synonyms: HJ2, SER2, sm, Serh, D12Ggc2e, mJagged2-1, serB, zgc:152855, JAG2

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Flow Cytometry (FACS), Immunofluorescence (IF)

Catalog no.: ABIN705791

Additional Information

Alternative name: Jagged 2

Immunogen: Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human Jagged 2

Format: Lyophilized

Reconstitution: Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%)

Isotype: IgG  (Matching secondary antibodies)

Description: Synonym: D12Ggc2e, HJ 2, HJ2, JAG 2, JAG2, Jagged 2 precursor, Jagged2, Syndactylism.

Molecular Weight: 120-135kDa

Comments:

Jagged 2 is a Notch ligand involved in the mediation of Notch signaling. Jagged 2 is expressed in heart

placenta and skeletal muscle and to a lesser extend in pancreas. Very low expression in brain

lung

liver and kidney. The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. Jagged 2 is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for Jagged 2.

Application Details

Application Notes: WB (1:100-500), ELISA (1:500-1000), IP (1:20-100), IHC-P (1:100-500), IHC-F (1:100-500), Flow-Cyt (1:20-100), IF (1:50-200)

Concentration: 1mg/1ml

Purification: affinity purified by Protein A

Buffer: 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Storage: Ship at room temperature. Store at -20°C

Restrictions: For Research Use only