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NUMB antibody (C-Term)
NUMB
Reactivity: Human, Mouse, Rat
WB, EIA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-NUMB Antibody
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Target
See all NUMB Antibodies
NUMB
(Numb Homolog (NUMB))
Binding Specificity
All epitopes for NUMB antibodies
C-Term
Reactivity
All reactivities for NUMB antibodies
Human, Mouse, Rat
Host
All hosts for NUMB antibodies
Rabbit
Clonality
All clonalities for NUMB antibodies
Polyclonal
Conjugate
All conjugates for NUMB antibodies
This NUMB antibody is un-conjugated
Application
All applications for NUMB antibodies
Western Blotting (WB), Enzyme Immunoassay (EIA)
Specificity
This antibody detects NUMB at C-term. At least four isoforms of NUMB are known to exist, this antibody will detect all of them.
Cross-Reactivity (Details)
Species reactivity (tested):Human, mouse, rat
Purification
Affinity chromatography purified via peptide column
Immunogen
17 amino acid peptide near the carboxy terminus of human NUMB
Top Product
Discover our top product NUMB Primary Antibody
Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Buffer
PBS containing 0.02 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Target Details for NUMB
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Target
NUMB
(Numb Homolog (NUMB))
Alternative Name
NUMB (NUMB Products )
Synonyms
C14orf41 antibody, S171 antibody, c14_5527 antibody, Nb antibody, NUMB, endocytic adaptor protein antibody, numb homolog (Drosophila) antibody, NUMB antibody, Numb antibody, numb antibody
Background
NUMB, the mammalian homolog to the Drosophila asymmetric cell fate determinant NUMB, is thought to share several features molecular mechanisms in mammalian cells, generating asymmetric cell divisions during neurogenesis in vertebrate development as well as in hematopoietic stem cells (1,2). NUMB has been shown to inhibit Notch signaling, and is itself regulated by ubiquitinylation by MDM2. NUMB has also been shown to help activate the tumor suppressor p53, suggesting that loss of NUMB in cancerous cells would not only activate the potential oncogene Notch, but diminish the tumor suppressing effect of p53.Synonyms: Protein S171, Protein numb homolog, h-Numb
Gene ID
8650
NCBI Accession
NP_001005743
UniProt
P49757
Pathways
Cell-Cell Junction Organization
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