PIAS4 antibody (N-Term)
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- Target See all PIAS4 Antibodies
- PIAS4 (Protein Inhibitor of Activated STAT, 4 (PIAS4))
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PIAS4 antibody is un-conjugated
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Cross-Reactivity (Details)
- Species reactivity (tested):Human, mouse, rat
- Purification
- Affinity chromatography purified via peptide column
- Immunogen
- 19 amino acid peptide near the amino terminus of human PIAS4
- Top Product
- Discover our top product PIAS4 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS containing 0.02 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- -20 °C
- Storage Comment
- Store the antibody (in aliquots) at -20 °C.
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- Target
- PIAS4 (Protein Inhibitor of Activated STAT, 4 (PIAS4))
- Alternative Name
- PIAS4 (PIAS4 Products)
- Synonyms
- PIASY antibody, Piasg antibody, ZMIZ6 antibody, pias4 antibody, piasy antibody, wu:fc54c11 antibody, wu:fi18c10 antibody, wu:fi20e09 antibody, wu:fk93f11 antibody, zgc:66410 antibody, piasg antibody, zmiz6 antibody, LOC100219439 antibody, Pias-gamma antibody, pias4l antibody, wu:fi26h11 antibody, zgc:63923 antibody, protein inhibitor of activated STAT 4 antibody, protein inhibitor of activated STAT, 4 antibody, protein inhibitor of activated STAT, 4a antibody, protein inhibitor of activated STAT 4 L homeolog antibody, protein inhibitor of activated STAT, 4b antibody, PIAS4 antibody, Pias4 antibody, pias4a antibody, pias4.L antibody, pias4 antibody, pias4b antibody
- Background
- The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS4. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS4 interacts with p53 and blocks its ability to induce Bax and p21 transcription. PIAS4 is also important in the control of the ubiquitin-dependent proteasomal degradation of the Ets-1 transcription factor. PIAS4 has been implicated in the DNA-damage response pathway and is thought to work in combination with PIAS1 for the productive association of 53BP1, BRCA1 and RNF168.Synonyms: E3 SUMO-protein ligase PIAS4, PIAS-gamma, PIASG, PIASy, Protein inhibitor of activated STAT protein 4, Protein inhibitor of activated STAT protein gamma
- Gene ID
- 51588
- NCBI Accession
- NP_056981
- UniProt
- Q8N2W9
- Pathways
- JAK-STAT Signaling, Interferon-gamma Pathway, Positive Regulation of Response to DNA Damage Stimulus
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