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NLR Family, Pyrin Domain Containing 13 (NLRP13) (N-Term) antibody

Details for Product No. ABIN783721, Supplier: Log in to see
Antigen
  • CLR19.7
  • NALP13
  • NOD14
  • PAN13
Epitope
N-Term
10
Reactivity
Human
11
Host
Rabbit
11
Clonality
Polyclonal
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
11
10
4
3
2
2
1
1
Supplier
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Immunogen 19 amino acid peptide near the amino terminus of human NALP13
Specificity This antibody detects NLRP13 at N-term.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Affinity chromatography purified via peptide column
Alternative Name NLRP13
Background NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP13 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. While little is known about the function of NALP13, it has been suggested that it may be implicated in the activation of proinflammatory caspases via inflammasomes.Synonyms: LRR and PYD domains-containing protein 13, NACHT, NALP13, NOD14
Gene ID 126204
NCBI Accession NP_789780
UniProt Q86W25
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-NLR Family, Pyrin Domain Containing 13 (NLRP13) (N-Term) antibody (ABIN783721) Western blot analysis of NALP13 in K562 cell lysate with NALP13 antibody at 1 μg/ml.
Background publications Tian, Pascal, Monget: "Evolution and functional divergence of NLRP genes in mammalian reproductive systems." in: BMC evolutionary biology, Vol. 9, pp. 202, 2009 (PubMed).

Tschopp, Martinon, Burns: "NALPs: a novel protein family involved in inflammation." in: Nature reviews. Molecular cell biology, Vol. 4, Issue 2, pp. 95-104, 2003 (PubMed).