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NOTCH3 antibody (C-Term)
NOTCH3
Reactivity: Human, Mouse, Rat
IHC (p), EIA
Host: Goat
Polyclonal
unconjugated
Product Details anti-NOTCH3 Antibody
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Target
See all NOTCH3 Antibodies
NOTCH3
(Notch 3 (NOTCH3))
Binding Specificity
All epitopes for NOTCH3 antibodies
C-Term
Reactivity
All reactivities for NOTCH3 antibodies
Human, Mouse, Rat
Host
All hosts for NOTCH3 antibodies
Goat
Clonality
All clonalities for NOTCH3 antibodies
Polyclonal
Conjugate
All conjugates for NOTCH3 antibodies
This NOTCH3 antibody is un-conjugated
Application
All applications for NOTCH3 antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
Sequence
C-QLGPQPEVTP KRQ
Specificity
Recognizes NOTCH3
Cross-Reactivity (Details)
Species reactivity (expected):Mouse, Rat. Species reactivity (tested):Human.
Purification
Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Immunogen
Peptide with sequence from the C Terminus of the protein sequence according to NP_000426.2.
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Discover our top product NOTCH3 Primary Antibody
Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for NOTCH3
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Target
NOTCH3
(Notch 3 (NOTCH3))
Alternative Name
NOTCH3 (NOTCH3 Products )
Synonyms
CADASIL antibody, CASIL antibody, IMF2 antibody, AW229011 antibody, N3 antibody, hpbk antibody, fa14b08 antibody, notch5 antibody, wu:fa14b08 antibody, notch 3 antibody, NOTCH3 antibody, Notch3 antibody, notch3 antibody
Background
NOTCH3 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. Defects in NOTCH3 are associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).Synonyms: Neurogenic locus notch homolog protein 3, Notch-3
Gene ID
4854
NCBI Accession
NP_000426
Pathways
Notch Signaling
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