Frataxin antibody (Middle Region)

Catalog No. ABIN785388

Product Details anti-Frataxin Antibody

Target: Frataxin (FXN)

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Horse, Rabbit, Cow, Guinea Pig, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Frataxin antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: TLDNPSSLDE TAYERLAEET LDSLAEFFED LADKPYTLED YDVSFGDGVL

Predicted Reactivity: Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 86%

Characteristics: This is a rabbit polyclonal antibody against Fxn. It was validated on Western Blot.

Purification: Affinity Purified

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 207 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for Frataxin

Target: Frataxin (FXN)

Alternative Name: Fxn (FXN Products)

Synonyms: zgc:158218 antibody, LOC100284365 antibody, BcDNA:AT09528 antibody, CG8971 antibody, DFH antibody, Dfh antibody, Dmel\\CG8971 antibody, X25 antibody, dfh antibody, CyaY antibody, FA antibody, FARR antibody, FRDA antibody, RGD1565754 antibody, Frda antibody, frataxin antibody, fxn antibody, LOC100284365 antibody, TVAG_182150 antibody, fh antibody, FTX1 antibody, FXN antibody, Fxn antibody

Background: Fxn promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved in these pathways. It may play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe2+ to Fe3+, the oligomeric form but not the monomeric form has in vitro ferroxidase activity. It may be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. It modulates the RNA-binding activity of ACO1.
Alias Symbols: FA, FARR, Frda, X25
Protein Size: 207

Molecular Weight: 23 kDa

Gene ID: 14297

NCBI Accession: NM_008044, NP_032070

UniProt: O35943

Pathways: Transition Metal Ion Homeostasis, Regulation of Cell Size