KIT antibody (C-Term)

Catalog No. ABIN870633

The Rabbit Monoclonal anti-KIT antibody is suitable to detect KIT in samples from Human. It has been validated for IHC (p).

Quick Overview for KIT antibody (C-Term) (ABIN870633)

Target: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This KIT antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: R21-V

Product Details anti-KIT Antibody

Binding Specificity: AA 957-973, C-Term

Purpose: Anti-CD117

Specificity: CD117

Immunogen: Peptide derived from C-terminal sequence of human CD117. Antibody recognizes the epitope between Ile957 - His973.

Isotype: IgG

Application Details

Application Notes: 1:100 - 200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 20 mM Tris-HCI, pH 8.0, Stabilizer: 20 mg/mL BSA, Preservative: 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: +2 °C to +8 °C

Target Details for KIT

Target: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Alternative Name: CD117

Background: This receptor tyrosine kinase, also known as proto-oncogene c-Kit, is expressed mostly at the surface of hematopoietic cells. Its altered expression and/or mutations are detected in several types of cancer. Overexpression of CD117 is associated with melanomas, seminomas, acute myeloid leukemia and gastrointestinal tumors.

UniProt: P10721

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity