Caspase 3, Apoptosis-Related Cysteine Peptidase (CASP3) (AA 29-33) antibody

Details for Product No. ABIN871646
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Antigen
Synonyms
xcpp32, Lice, CPP32, SCA-1, CPP32B, CC3, CG14902, Cas3, Casp 3, Casp3, Caspase-3, DECAY, Decay, Dmel\\CG14902, Drosophila executioner caspase related to Apopain/Yama, caspase 3, caspase-3, CG7788, DRI ... show more
xcpp32, Lice, CPP32, SCA-1, CPP32B, CC3, CG14902, Cas3, Casp 3, Casp3, Caspase-3, DECAY, Decay, Dmel\\CG14902, Drosophila executioner caspase related to Apopain/Yama, caspase 3, caspase-3, CG7788, DRICE, Dmel\\CG7788, DrICE, DrIce, Drice, ICE, crice, drICE, drIce, drice, ice show less
Epitope
AA 29-33
(24), (20), (14), (13), (12), (11), (7), (7), (6), (6), (4), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(279), (104), (90), (20), (18), (17), (5), (5), (4), (4), (4), (3), (2), (2), (2), (1)
Host
Rabbit
(249), (54), (7), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(10), (5), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(253), (95), (94), (91), (52), (22), (15), (15), (14), (12), (10), (4), (4), (2), (2), (2), (1)
Pubmed 2 references available
Catalog no. ABIN871646
Quantity 100 µL
Price
220.00 $   Plus shipping costs $45.00
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Immunogen Peptide sequence around AA 29-33 (S-G-I-S-L) derived from Caspase 3. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Specificity The antibody detects endogenous level of total Caspase 3 protein.
Purification Affinity purified
Alternative Name Caspase 3
Background Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
Molecular Weight 17 kDa
Gene ID 836
NCBI Accession NP_004337
UniProt P42574
Research Area Proteolysis / Ubiquitin, Apoptosis/Necrosis
Application Notes Western blotting: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Background publications Nicholson, Ali, Thornberry et al.: "Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis." in: Nature, Vol. 376, Issue 6535, pp. 37-43, 1995 (PubMed).

Gervais, Xu, Robertson et al.: "Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation." in: Cell, Vol. 97, Issue 3, pp. 395-406, 1999 (PubMed).

Hosts (249), (54), (7), (2)
Reactivities (279), (104), (90), (20), (18), (17), (5), (5), (4), (4), (4), (3), (2), (2), (2), (1)
Applications (253), (95), (94), (91), (52), (22), (15), (15), (14), (12), (10), (4), (4), (2), (2), (2), (1)
Conjugates (10), (5), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (24), (20), (14), (13), (12), (11), (7), (7), (6), (6), (4), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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