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Casein Kinase II alpha Subunit (CKIIALPHA) (AA 353-357) antibody

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AA 353-357
(2), (2), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(7), (3), (2), (1), (1)
Western Blotting (WB)
(7), (1)
Pubmed 4 references available
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Quantity 100 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 3 Business Days
Immunogen Peptide sequence around AA 353-357 (C-S-G-I-S) derived from Human CK2a. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
Specificity The antibody detects endogenous levels of total CK2 protein.
Purification Affinity purified
Alternative Name CK2alpha
Background Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The a and a' chains contain the catalytic site. Participates in Wnt signaling. CK2 phosphorylates 'Ser-392' of p53/TP53 following UV irradiation.
Molecular Weight 42 kDa
Gene ID 1495
NCBI Accession NP_001894
UniProt P68400
Application Notes Western blotting: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Background publications Trembley, Tatsumi, Sakashita et al.: "Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation." in: Molecular and cellular biology, Vol. 25, Issue 4, pp. 1446-57, 2005 (PubMed).

Keller, Lu: "p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex." in: The Journal of biological chemistry, Vol. 277, Issue 51, pp. 50206-13, 2002 (PubMed).

Keller, Zeng, Wang et al.: "A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1." in: Molecular cell, Vol. 7, Issue 2, pp. 283-92, 2001 (PubMed).

Niefind, Guerra, Ermakowa et al.: "Crystallization and preliminary characterization of crystals of human protein kinase CK2." in: Acta crystallographica. Section D, Biological crystallography, Vol. 56, Issue Pt 12, pp. 1680-4, 2001 (PubMed).

Catalog No. ABIN871699
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