HAX1 antibody (AA 191-279) (Cy7)

Catalog No. ABIN900159

Product Details anti-HAX1 Antibody (Cy7)

Target: HAX1 (HCLS1 Associated Protein X-1 (HAX1))

Binding Specificity: AA 191-279

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HAX1 antibody is conjugated to Cy7

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HAX1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for HAX1

Target: HAX1 (HCLS1 Associated Protein X-1 (HAX1))

Alternative Name: HAX1 (HAX1 Products)

Synonyms: HAX1 antibody, hax1 antibody, HCLSBP1 antibody, HS1BP1 antibody, SCN3 antibody, HAX-1 antibody, Hs1bp1 antibody, HSP1BP-1 antibody, SIG-111 antibody, Silg111 antibody, mHAX-1s antibody, HCLS1 associated protein X-1 antibody, HCLS1 associated X-1 antibody, HAX1 antibody, hax1 antibody, Hax1 antibody

Background:

Synonyms: HAX 1, Hax1a, HCLS1 and PKD2 associated protein, HCLS1 associated protein, HCLS1 associated protein X 1, HCLSBP1, HS 1 associated protein X 1, HS 1 binding protein, HS1 associating protein X 1, HS1 binding protein 1, HS1 binding protein, HS1BP1, SCN3.

Background: RelevanceHAX1 associates with HS1, binding to its N-terminal region. It is also known to associate with PKD2 (involved in polycystic kidney disease) and with cortactin/EMS1. HAX1 is also reported to bind to hairpin structures in vimentin and DNA polymerase beta mRNAs, so may play a role in mRNA stability and transport. It may also function in promoting cell survival. Defects in HAX1 are the cause of autosomal recessive severe congenital neutropenia 3 (SCN3) also called Kostmann disease.

Gene ID: 10456

Pathways: Regulation of Actin Filament Polymerization